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Amoxicillin and Clavulanate Potassium Augmentin Tablet

Amoxicillin and Clavulanate Potassium Augmentin Tablet
  • Waters Corporation
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This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief highlights about analysis of amoxicillin and clavulanate tablets using symmetry C8 Column.

Introduction

Structures

Experimental

HPLC Method

Column:

Symmetry C8, 3.9 x 150 mm, 5 µm

Part number:

WAT046980

Mobile phase:

56 mM sodium phosphate, pH 4.4/methanol 95:5

Flow rate:

1.0 mL/min

Injection volume:

10 µL of 100 µg/mL amoxicillin and 25 µg/mL clavulante extracted tablet sample at 10 to 39 µg/mL

Detection:

UV @ 220 nm

USP Tailing Factors

  1. 1.2 
  2. 1.1 

Results and Discussion

The compouds analyzed in this study are:

  1. Clavulanate
  2. Amoxicillin 

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WA31763.23, June 2003

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