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Atorvastatin - XTerra RP18 

Atorvastatin - XTerra RP18 
  • Waters Corporation
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Atorvastatin cholesterol lowering drug chemical structure

This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief demonstrates the analysis of atrovastatin using XTerra RP18 Columns. 

Introduction

In this study the compound analyzed is atorvastatin. 

Atorvastatin

Experimental

Conditions

Column:

XTerra RP18 4.6 x 100 mm, 3.5 µm

Part number:

186000438

Mobile phase A:

10 mM NH4COOH, pH 3.0

Mobile phase A:

10 mM NH4HCO3, pH 7.0

Mobile phase A:

10 mM NH4HCO3, pH 10.0

Mobile phase B:

ACN

Isocratic Conditions as Indicated

Flow rate:

1.4 mL/min

Injection volume:

2 µL

Sample Concentration:

0.25 mg/mL

Temperature:

30 °C

Detection:

UV @ 254 nm

Instrument:

Alliance 2795 HT, 2996 PDA

Mobile Phase pH

USP Tailing

3.0

1.04

7.0

1.19

10.0

1.11

Results and Discussion

Atorvastatin

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WA20738.014, June 2002

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