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Four Drug Mixture- Warfarin, Dextromethorphan, Triprolidine, and Tetracaine

Four Drug Mixture- Warfarin, Dextromethorphan, Triprolidine, and Tetracaine
  • Waters Corporation
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Medicines in a pharmacy

This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief demonstrates analysis of four drug mixture- warfarin, dextromethorphan, triprolidine, and tetracaine.

Introduction

The compounds used in this study are –

Compounds

USP Tailing Factors

Warfarin

1.3

Dextromethorphan HCL

1.6

Triprolidine HCL

1.1

Tetracaine

1.2

Experimental

HPLC Method

Column:

Symmetry Shield RP18, 3.9 x 150 mm, 5 μm

Part number:

186000108

Mobile phase A:

25 mM Potassium phosphate, pH 7

Mobile phase B:

Methanol

Flow rate:

1.0 mL/min

Injection volume:

10 μL of mixture with 0.3 mg/mL triprolidine, 0.4 mg/mL dextromethorphan, 0.15 mg/mL tetracaine, and 0.05 mg/mL of warfarin

Detection:

UV @ 280 nm

Gradient

Gradient.

Results and Discussion

Featured Products

WA31763.87, June 2003

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