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Fractionation of Acidic and Neutral from Basic Drugs in Plasma

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This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief demonstrates fractionation of acidic and neutral from basic drugs in plasma.

Introduction

The compounds used in this study are -

Acetaminophen
Barbital
p-Toluamide
Amphetamine
Methamphetamine
m-Toluidine
Ranitidine (I.S.)

Experimental

LC Conditions

Column:	Symmetry Shield RP₈, 4.6 x 75 mm, 3.5 μm
Guard column:	Symmetry Shield RP₈, 3.9 x 20 mm, 3.5 μm
Part numbers:	Column WAT094263, Guard 186000704
Mobile phase:	5% CH₃OH/95% 20 mM K₂HPO₄/KH₂PO₄, pH 7
Flow rate:	2 mL/min
Temperature:	36 °C
Injection:	10 μL plasma extract
Detection:	UV @ 214 nm (0.010 AUFS)

Results and Discussion

HPLC Chromatogram of Elute 1 and Elute 2 Fraction

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Fractionation of Acidic and Neutral from Basic Drugs in Plasma

Abstract

Introduction

Experimental

LC Conditions

Results and Discussion

HPLC Chromatogram of Elute 1 and Elute 2 Fraction

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