The Waters GTxResolve 2000 Å SEC column, MaxPeak Premier 3 µm is designed with low-adsorption MaxPeak hardware and advanced bridged ethylene HO-PEO particles. This innovative composition ensures high recovery for GTx drugs ranging from 800 to 2500 Å in diameter, including lipid nanoparticles (LNPs), plasmids, and viral vectors. Engineered for extended column lifetimes, minimal secondary interactions, and enhanced MALS sensitivity, this solution supports the development of multi-attribute platform methods. It enables comprehensive integrity and heterogeneity analyses of LNP formulations, plasmid topology assessments, and improved detection of ejected transgenes and aggregates in viral vector applications.
| 
                             Chemistry  | 
                        
                             SEC  | 
                    
| 
                             Separation Mode  | 
                        
                             SEC  | 
                    
| 
                             Particle Substrate  | 
                        
                             Silica  | 
                    
| 
                             pH Range Min  | 
                        
                             2.5 pH  | 
                    
| 
                             pH Range Max  | 
                        
                             8 pH  | 
                    
| 
                             Temperature Limits  | 
                        
                             60 C  | 
                    
| 
                             Maximum Pressure  | 
                        
                             2000 psi (140 Bar)  | 
                    
| 
                             Endcapped  | 
                        
                             No  | 
                    
| 
                             Bonding Technology  | 
                        
                             SEC  | 
                    
| 
                             Silanol Activity  | 
                        
                             Low  | 
                    
| 
                             Particle Shape  | 
                        
                             Spherical  | 
                    
| 
                             Particle Size  | 
                        
                             3 µm  | 
                    
| 
                             Endfitting Type  | 
                        
                             Parker-style  | 
                    
| 
                             Pore Size  | 
                        
                             2000 Å  | 
                    
| 
                             Format  | 
                        
                             Premier Column  | 
                    
| 
                             Surface Area  | 
                        
                             19  | 
                    
| 
                             System  | 
                        
                             UHPLC, UPLC, HPLC  | 
                    
| 
                             Particle Technology  | 
                        
                             Silica  | 
                    
| 
                             Technique  | 
                        
                             SEC  | 
                    
| 
                             USP Classification  | 
                        
                             L33  | 
                    
| 
                             Inner Diameter  | 
                        
                             4.6 mm  | 
                    
| 
                             Length  | 
                        
                             150 mm  | 
                    
| 
                             Carbon Load  | 
                        
                             1.2 %  | 
                    
| 
                             UNSPSC  | 
                        
                             41115709  | 
                    
| 
                             Application  | 
                        
                             Gene Therapeutics  | 
                    
| 
                             Brand  | 
                        
                             GTxResolve  | 
                    
| 
                             Product Type  | 
                        
                             Columns  | 
                    
| 
                             Units per Package  | 
                        
                             1 pk  | 
                    
| 
                             eConnect  | 
                        
                             No  |