• Application Note

Anticonvulsants

Anticonvulsants
  • Waters Corporation
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This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief details on the analysis of Anticonvulsants using Symmetry Columns.

Introduction

Compounds
Compounds

Experimental

HPLC Method

Column:

Symmetry C8, 3.9 x 150 mm, 5 µm

Part number:

WAT046970

Mobile phase:

100 mM potassium phosphate, pH 6.9/acetonitrile/water 20:30:50

Flow rate:

1.0 mL/min

Injection volume:

10 µL of 11–160 µg/mL sample

Temperature:

30 °C

Detection:

UV @ 214 nm

USP Tailing Factors

  1. 1.41 
  2. 1.03 
  3. 1.11 
  4. 1.02 
  5. 1.07 

Results and Discussion

The compounds analyzed in this study are:

  1. Succinimide 
  2. Primidone  
  3. Phenobarbital 
  4. Mephenytoin 
  5. Mephobarbital 

Featured Products

WA31763.28, June 2003

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