Heater-Shaker+
Programmable heating and shaking for automated and manual workflows
Deliver repeatable mixing and temperature control for plates and tubes—whether you run walk‑away automation with Andrew+ or execute protocols manually with OneLab Software guidance.
- Heat and shake in one compact device: heating from ambient to 99 °C and shaking 200–2,500 rpm for demanding lab workflows.
- Designed for automation, friendly for manual use: built for robotic workflows and also supported in manual execution with OneLab Software prompts.
- Connected control and traceability: connect via Wi‑Fi/Ethernet to OneLab Software for remote control and workflow tracking.
- Flexible labware coverage with interchangeable adaptors: swap plate adaptors as your labware and workflows evolve.
Heater-Shaker+
Specifications
Overview
- Enable remote control and tracking through OneLab Software via Wi-Fi or Ethernet connectivity
- Achieve faster, gentler mixing of samples by planar orbital motion using an ultra-efficient, 2-dimensional shaking axis
- Ensure fully adjustable mixing speeds between 200 and 2,500 rpm for both tubes and plates
- Achieve rapid and homogenous heating from ambient temperatures up to 99°C enabled by a large‑area heating source and digital sensor, with temperatures selectable in 1.0 °C steps
- Maintain rapid, repeatable, and accurate microplates positioning, ensuring safe, fast mixing processes with frequent plate changes
- Improve loading, removal, and pipetting accuracy with locked zero-positioning control
Recommended Use: For programmable high-speed mixing and precise temperature control across demanding laboratory applications.
Flexible labware compatibility with interchangeable adaptors
Workflows change—your device shouldn’t limit you. Heater‑Shaker+ supports a broad range of labware through dedicated, interchangeable adaptors. Swap adaptors to match the labware you need today (PCR plates, deepwell plates, flat‑bottom plates, cryovials, bottles, and more), and change them later as your SOPs evolve—without replacing the device.
Built for automation — friendly for manual execution
Heater‑Shaker+ provides reliable heating and shaking for plates and tubes, adapting to manual or automated workflows. In manual mode, OneLab Software guides users through labware loading while the device handles pre-heating, clamping, and shaking automatically. Paired with Pipette+, pipetting instructions are sent in real time for a traceable bench workflow, coordinating incubation and mixing from a single interface and minimizing manual steps. For full automation, Heater‑Shaker+ integrates with the Andrew+ pipetting robot, allowing protocols to be designed once and automated later, ensuring consistent and digitally documented processing throughout.
Applications
- Plate-Based Immunoassays (ELISA): Provides the uniform temperature and gentle orbital shaking necessary for consistent antibody-antigen binding and washing steps across a microplate.
- Endotoxin Testing: Fits perfectly into LAL-based assays that rely on strict temperature control (often exactly 37 °C) and precise incubation times.
- Enzymatic Reactions: Maintains the optimal thermal environment for enzyme kinetics while ensuring substrates and enzymes are homogeneously mixed.
- Sample Resuspension & Homogenization: Efficiently resuspends difficult pellets, cells, and magnetic beads using its high-speed, 2-dimensional planar shaking axis.
- Derivatization: Drives chemical labeling reactions (such as tagging glycans or amino acids for LC-MS analysis) that require elevated temperatures to reach completion.
- Serial Dilutions: Ensures thorough mixing between dilution steps in a multi-well plate or tube format, reducing operator-to-operator variability.
- Bacterial & Cell Growth: Can be used for small-scale cell culture incubations in deep-well plates or tubes requiring gentle agitation and incubation.
Resources
Support
What do you want to do?
Frequently Asked Questions
What are the key benefits of Heater-Shaker+?
- Traceability — Speed, temperature, and timing are captured the moment they're applied, with no user effort. The OneLab Software record stays ready for audit at any point.
- Reproducibility — Heating from ambient to 99 °C in 1 °C steps and shaking from 200 to 2,500 RPM are programmed from the same interface. The two-dimensional planar orbital motion keeps mixing even and free of vibration, run after run.
- Productivity — Programs launch from a browser, so there's no walking back to the bench to tweak settings, and the large-area heating source reaches setpoint quickly. With Pipette+ Stand or Andrew+ Robot in the chain, heating and mixing fire as protocol steps.
- Automation Readiness — Robot-ready by design. The edge lock mechanism (ELM) and 0.1 mm zero-positioning give pipettes a reliable target every time. The protocol you write by hand is the protocol Andrew+ will run.
Which lab scenarios are ideal for Heater-Shaker+?
- Compliance-driven workflows — Replace the untracked heater-shaker with one that hands QA and auditors a complete electronic record of every heat cycle and mixing action.
- Temperature-dependent assays — Protein digestion, enzymatic reactions, cell lysis, and denaturation all rely on holding temperature steady while the sample moves; Heater-Shaker+ does both at once, up to 99 °C.
- Manual-to-automation transition — Develop and check the method by hand, then hand the same protocol to Andrew+ Robot when you're ready to scale. Nothing needs to be reworked.
What are the traceability, compliance, and integration benefits?
Speed, temperature, duration, timestamps, and labware ID all flow straight into the protocol log — no separate logbook to maintain. The resulting electronic record meets GxP, GLP/GMP, and 21 CFR Part 11 expectations, and it is stored in the same place as pipetting (Pipette + Stand/Andrew + Robot) and other connected device logs (Shaker+, Peltier+, Magnet+, Extraction+).
What applications are ideal for Heater-Shaker+?
Any workflow where temperature, mixing, and documentation affect the result:
Protein extraction and digestion (e.g., tryptic digests at 37 °C)
Cell lysis and resuspension
Nucleic acid extraction, denaturation, and clean-up
ELISA and plate-based immunoassays
Endotoxin testing (LAL assays)
Enzymatic reactions and incubations
Serial dilutions with controlled temperature
Amino acid analysis
General bioanalytical and QC sample prep
Also widely used in genomics, proteomics, drug discovery, and clinical research.
What labware is compatible with Heater-Shaker+?
Interchangeable adaptors handle HP, LP, deepwell, flat-bottom, and solid base plates, along with cryovials and ø36.5 mm bottles. The full and continually growing list lives in the OneLab Domino Catalog.
Can I use Heater-Shaker+ without Andrew+ Robot?
Yes. The device pairs with OneLab Software over Wi-Fi or Ethernet on its own, keeping the same remote control and traceability whether or not a robot is nearby.
What is the difference between Heater-Shaker+ and Shaker+?
Heater-Shaker+ — Heating (ambient to 99 °C) plus shaking up to 2,500 RPM, with adaptors covering plates, cryovials, and bottles. Shaker+ — Shaking only, reaching 3,000 RPM (microplate) or 2,000 RPM (tubes), with a dedicated tube model.
Reach for Heater-Shaker+ when temperature is part of the method (e.g., 37 °C digestion with shaking). Reach for Shaker+ when ambient mixing is all you need.
How does Heater-Shaker+ connect to my network?
Dual-band Wi-Fi (2.4/5 GHz) or Gigabit Ethernet. Once online, any browser on the network handles setup, monitoring, and log review — nothing to install per machine.
