Xevo MRT P10 Mass Spectrometer

Accelerating the benefits of pioneering science in research and discovery

Enhanced MS/MS sensitivity delivers high quality data for confident identification and quantification of low abundance components, including single cell analyses. For example, this enables the identification of up to 40% more lipids compared with the next best benchtop HRMS. When combined with ultrafast scan speeds, the Xevo MRT P10 MS ensures comprehensive data capture even during rapid chromatographic separations—without compromising mass spectral data quality.

For seamless data integration and ultimate flexibility, the waters_connect Software platform converts datasets into the universal mzML format during acquisition or post processing, supporting integration into existing workflows and data pipelines.

Enabling multiomics insight

Modern biological research increasingly depends on integrated multiomics mass spectrometry strategies. The Xevo MRT P10 MS is designed to meet the needs of core facilities and research laboratories supporting discovery, quantitative, and translational applications.

Exceptional MS and MS/MS sensitivity combined with ultrafast acquisition speed enables deep proteome coverage from complex samples. High quality fragmentation spectra and accurate mass measurements improve peptide identification confidence, supporting comprehensive bottom up proteomics using the SONAR Pulse Acquisition Mode or advanced DDA workflows.

Powerful methods for extending analytical depth

Achieve deeper analytical insight through flexible, advanced DDA and DIA modes optimized for complex, real world samples. In addition to traditional DIA and advanced DDA with enhanced decision-making criteria, the Xevo MRT P10 MS offers:

Hybrid targeted and untargeted acquisition

Combined data acquisition of multiple scan types within a single injection. The fast scanning >100Hz speed and exceptional sensitivity enable collection of multiple Tof MRM transitions without compromising simultaneous DIA performance—ideal for advanced quantification and discovery workflows.

SONAR Pulse Acquisition Mode

The SONAR Pulse Acquisition Mode simplifies method set-up and reduces bias introduced in conventional DDA experiments while retaining highly specific MS/MS fragmentation information. SONAR Pulse Acquisition Mode combines a full scan MS with rapid, stepping quadrupole MS/MS, delivering improved precursor–fragment specificity while retaining the reproducibility and completeness of DIA.

Visualization redefined

When combined with DESI XS Source, the outstanding sensitivity and speed of the Xevo MRT P10 MS makes high spatial resolution MS imaging a reality, with 100K (FWHM) mass resolution and class-leading speeds of up to 200 Hz. With this combination, you gain molecular visualization without compromise, expanding analytical possibilities for spatial biology at the cellular level.

Setting a new benchmark in performance

Exceptional spectral quality—including mass accuracy, resolution, and isotopic fidelity in both MS and MS/MS—supports tighter mass tolerances, resulting in fewer candidate identifications, and faster, more confident results.

By combining industry-leading sensitivity, unmatched acquisition speed, and advanced acquisition modes in a compact benchtop platform, the Xevo MRT P10 MS enables laboratories to accelerate the benefits of pioneering science.