Long nucleic acids / transgene sequences in cell and gene therapies range from 1,000 to 10,000+ nucleotides in length. Confirming their identity and purity is critically important to ensuring the safety and efficacy of these new modalities. Waters chromatography columns and systems combined with optical detection and/or mass spectrometry provide powerful capabilities for confirming the physicochemical properties of these nucleic acids and of their fully assembled drug product when packaged into lipid nanoparticles (LNPs), viral vectors (e.g. AAV), or virus-like-particles (VLPs) for cell delivery.
On-Demand Webinar: LC-MS CQA Analysis of RNA Therapeutics