• Application Note

Clemastine in Rat Plasma- Oasis On-Line 2 Column Parallel Approach

Clemastine in Rat Plasma- Oasis On-Line 2 Column Parallel Approach
  • Waters Corporation
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This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief highlights about the analysis of clemastine in rat plasma.

Introduction

The compound analyzed in this sutudy was clemastine

Experimental

HPLC Condition

LC1:

Alliance 2790–0.4 mL/min

LC2:

Waters 515–4.0 mL/min

Loading mobile phase:

100% Water

Eluting mobile phase:

1 min gradient 5% ACN to 95% ACN

Loading mobile phase additive:

0.5% Formic Acid or NH4OH

Extraction column temp.:

40 °C

Switching valve:

Rheodyne LabPro 10 ports, 2 position

MS Condition

MS:

Quatro UltimaTriple Quadrupole

Source:

Electrospray positive

Source temperature:

150°C

Desolvation gas:

600L/hr

Gas cell:

1.5e-3 mbar

Cone voltage:

20 volts

Collision energy:

20

Results and Discussion

Featured Products

WA31764.60, June 2003

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