Cell and Gene Therapies

Cell and Gene Therapies

Advanced analytical tools for biomolecular separations, mass spectrometry, and biophysical characterization

Advanced analytical tools for biomolecular separations, mass spectrometry, and biophysical characterization
HPS oligonucleotide preparative columns ensure high recovery, consistent and reliable impurity profiling from the very first injection.

From genetic material to delivery vehicles, analyze critical quality attributes with GMP-ready solutions for the enhanced performance and productivity your pipeline demands

Synthetic Oligonucleotides

Pipelines expand, molecules complexify. Your analytics must keep pace.

Pipelines expand, molecules complexify. Your analytics must keep pace.
  • Accelerate pipeline success: Navigate the expanding preclinical and clinical landscape for short-chain nucleic acid drugs with ease.
  • Ensure product integrity: Confirm absolute identity and purity of therapeutic candidates using leading-edge LC-MS tools.
  • Optimize bioanalysis: Streamline DMPK studies with precise extraction and quantification from complex biological samples.
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stock-antibody-illustration-protein-a.jpg

Nucleic Acids

From 500 to 10,000+ nucleotides. Leave no detail to chance.

From 500 to 10,000+ nucleotides. Leave no detail to chance.
  • Comprehensive payload profiling: Ensure the safety of mRNA, ssDNA, and dsDNA by assessing integrity, heterogeneity, and purity with integrated LC-MS and light scattering.
  • Deep mRNA characterization: Verify 5’ capping, 3’ poly-A tailing, and sequence mapping using automated workflows to ensure translation efficiency and stability.
  • Critical process control: Confirm plasmid linearization efficiency and accurate concentration to prevent premature termination and ensure consistent therapeutic dosing.
  • Advanced particle analysis: Mitigate safety risks and avoid recalls by identifying subvisible particles using only 5 µL of sample with BMI and FMM technology.
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Adeno associated virus

Viral Vectors

Biology is variable. Your results shouldn't be.

Biology is variable. Your results shouldn't be.
  • Comprehensive characterization: Master engineered virus complexity with integrated LC, MS, CDMS, and particle analysis.
  • Precision at every level: Analyze intact and component-level attributes, from viral titer to encapsulation efficiency.
  • Reliable performance: Ensure potency, purity and safety with automated, compliance-ready workflows built for productivity.
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Adeno associated virus

Lipid Nanoparticles

Structure, formulation, stability. Bring every detail into focus.

Structure, formulation, stability. Bring every detail into focus.
  • Master compositional analysis: Quantify lipid components and identify impurities with robust LC-UV, CAD and MS workflows to ensure formulation consistency.
  • Confirm particle integrity: Accurately assess size, polydispersity, and morphology using integrated dynamic light scattering and microcalorimetry for total stability insights.
  • Maximize payload confidence: Optimize every stage from raw material screening to final payload analysis with compliance-ready, high-sensitivity tools.
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Illustration of lipid nanoparticles used for mRNA delivery in cell and gene therapy analysis.
Bioreactors in a lab

Bioprocess Solutions

Complex scaling. Total control.

Complex scaling. Total control.
  • Real-time monitoring: Track critical quality attributes and media components directly on the shop floor to optimize yield and consistency.
  • Seamless method transfer: Ensure absolute reproducibility from R&D to manufacturing with robust, compliance-ready LC-MS systems.
  • Mitigate downstream risk: Detect impurities and monitor stability early to prevent batch failures and accelerate release timelines.
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Bioreactors in a lab
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