• Application Note

Oxybutynin in Rat Plasma

Oxybutynin in Rat Plasma
  • Waters Corporation
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Doctor with mask and gloves holds in hand test tube with separated plasma

This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief highlights the analysis of oxybutynin using XTerra MS C18 columns.

Introduction

Oxybutynin in rat plasma has been studied in this application brief.

Experimental

HPLC Conditions

Column:

XTerra MS C18 2.1 x 30 mm, 3.5 μm (p/n: 186000398)

Mobile phase A:

1.0% NH4OH

Mobile phase B:

ACN

Isocratic mobile phase composition:

45% A; 55% B

Flow rate:

0.2 mL/min

Injection volume:

30 μL

Detection:

MS ESI+

Instrument:

Alliance 2790, Micromass Quattro Ultima

MS Conditions

Ion source:

ESI+

Source temp.:

150 °C

Gas cell:

1.5e-3 mbar, 25 eV

Desolvation temp.:

350 °C

Cone gas flow:

150 L/hr

Drying gas flow:

600 L/hr

Cone voltage:

30 V

Results and Discussion

Featured Products

WA20738.083, June 2002

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