• 应用纪要

Ecstasy (MDMA) and Metabolites

Ecstasy (MDMA) and Metabolites
  • Waters Corporation
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This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief demonstrates analysis of ecstasy (MDMA) and metabolites.

Introduction

The compounds used in this study are –

  1. 4-Hydroxy-3-methoxymetmamphetamine (HMMA)
  2. 3,4-Methylenedioxyamphetamine (MDA)
  3. MDMA-D5 (ISTD)
  4. 3,4-Methylenedioxymethamphetamine (MDMA)

Experimental

Conditions

Column:

Xterra MS C18 2.1 x 150 mm, 3.5 μm

Part number:

186000408

Mobile phase A:

20 mM NH4HCO3, pH 9.0

Mobile phase B:

MeOH

Flow rate:

0.2 mL/min

Isocratic mobile phase composition:

70% A; 30% B

Injection volume:

15 μL

Temperature:

30 °C

Detection:

MS ESI+

Instrument:

Alliance 2695, Micromass ZQ

MS Conditions

Micromass ZQ ESI+

Capillary (KV):

3.0

Cone (V):

30

Extractor:

3.0

RF Lens:

0.5

Source temp.:

150

Desolvation temp.:

350

Cone gas flow (L/Hr):

50

Desolvation gas flow (L/Hr):

500

LM resolution:

15

HM resolution:

15

Ion energy:

0.1

Multiplier (V):

650

Results and Discussion

Featured Products

WA20738.047, June 2002

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