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Tamoxifen – Isolation of Impurities, Transfer from Analytical to Prep

Tamoxifen – Isolation of Impurities, Transfer from Analytical to Prep
  • Waters Corporation
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This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief highlights the Tamoxifen impurities isolation and transfer from analytical to prep using Symmetry and SymmetryPrep Columns.

Introduction

Compound used in this study is Tamoxifen Citrate.

Experimental

HPLC Method

Columns:

Symmetry C18, 3.0 x 150 mm, 5 μm (p/n:186000109)

SymmetryPrep C18, 7.8 x 300 mm, 7 μm (p/n: WAT066235)

Mobile phase:

Acetonitrile/50 mM potassium phosphate buffer, pH 3.0 40:60

Flow rate:

A. 0.4 mL/min B. 5.6 mL/min

Injection volume:

5 mg/mL tamoxifen citrate

A. 15 mg B. 101 mg

Detection:

UV @ 254 nm

Results and Discussion

Featured Products

WA31763.163, June 2003

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