Xevo TQ-XS Triple Quadrupole Mass Spectrometer

API sources and ionization modes

High performance ZSpray™ dual-orthogonal API sources:

1) Multi-mode source – tool free ESI/APCI/ESCi™* (standard)

NB – Dedicated APCI requires an additional probe (optional)

2) UniSpray™ ion source (optional)

3) Tool-free APCI probe (optional)

4) nanoFlow™ ESI source* (optional)

5) ASAP* (optional)

6) APGC ion source (optional)

7) ionKey™ source* (optional)

Optimized gas flow dynamics for efficient ESI desolvation

Tool-free source exchange

Vacuum isolation valve

Tool-free access to user serviceable elements

Plug-and-play probes

De-clustering cone gas

Software control of gas flows and heating elements

UniSpray ion source option

UniSpray is an ionization technique designed to broaden the scope of compounds which can be analyzed in a single run, including those which typically optimize in ESI, APCI or APPI. Enhanced ionization efficiency and desolvation allow the potential to combine several methodologies into one, or simply enable the operator to keep the same source for multiple methods, requiring less time performing set-up and routine maintenance, and more time delivering results

Ion source transfer optics

StepWave XS ion transfer optics delivering class leading UPLC™-MS/MS sensitivity. The unique off-axis design and segmented quadrupole second stage dramatically increases the efficiency of ion transfer from the ion source to the quadrupole MS analyzer at the same time as actively eliminating undesirable neutral contaminant

Mass analyzer

Two high-resolution, high-stability quadrupole analyzers (MS1/MS2), plus pre-filters to maximize resolution and transmission while preventing contamination of the main analyzers

Collision cell

T-Wave™ enabled for optimal MS/MS performance at high data acquisition rates;

Software programmable gas control

Detector

Low-noise, off-axis, long-life photomultiplier XDR detector

Vacuum system

Three air-cooled turbomolecular vacuum pumps One vacuum backing pump

Dimensions

Width: 61.0 cm (24.0 in.)

Height: 70.7 cm (27.8 in.)

Depth: 99.5 cm (39.0 in.)

Regulatory approvals/marks

CE, CB, NRTL (CAN/US), RCM

Software

Systems supported on waters_connect and MassLynx™ version 4.2 or later

System setup and method development

System parameter checks and alerts Integrated sample/calibrant delivery system + programmable divert valve

Automated mass calibration

Automated sample tuning

Automated MRM method development

UPLC-MS/MS System Check-on-column performance test

Automated MRM scheduling

(acquisition rate assignment)

Dwell time, inter-channel delay time and inter-scan delay time for individual channelsin a Multiple MRM experiment can be automatically assigned (using the Auto-Dwell feature) to ensure that the optimal number of MRM data points per chromatographic peak are acquired. The Auto-Dwell feature dynamically optimizes MRM cycle times to accommodate retention time windows that overlap. This greatly simplifies MRM method creation, irrespective of the number of compounds in a single assay, while at the same time ensuring the very best quantitative performance for every experiment

waters_connect software

The waters_connect software provides a modern user experience with a HUB design and apps that provide a consistent connected user experience across all applications. It is built for applications with convenient access to scientific apps allowing accelerated time-to-results and result quality. There are common utilities that complete the end-to-end workflow and help increase productivity and efficiency. Confidently report results with accurate, reliable, regulation-standard data from application-focused quantitative workflows with built in traceability for utmost integrity.

Acquisition modes

Full scan MS

Product ion scan

Precursor ion scan

Constant neutral loss scan

Multiple reaction monitoring (MRM) Simultaneous Full scan and MRM (RADAR)

RADAR

An information rich acquisition approach that allows you to collect highly specific quantitative data for target compounds while providing the ability to visualize all other components

Mass range

2 to 2048 m/z