Waters Cyclic IMS P20 Mass Spectrometer
Insight—revealed, not inferred
Whether advancing discovery in academia or innovation in industry, the next generation Cyclic IMS P20 Mass Spectrometer delivers clearer, more confident interpretation of complex biology. By combining high‑resolution cyclic ion mobility with precise mass analysis it separates co‑eluting and isomeric species, simplifying complex ion populations and enabling more interpretable data.
The result: confident structural hypotheses and deeper insight across demanding workflows.
Waters Cyclic IMS P20 Mass Spectrometer
Overview
- Cyclic ion mobility resolves isomeric and co‑eluting species, revealing structural detail hidden in conventional LC‑MS.
- Mobility‑enabled selection before and after fragmentation simplifies complex spectra and strengthens assignment confidence.
- Multi‑pass separations increase mobility resolution, distinguishing closely related species.
- Wideband Enhancement (WBE) boosts MS/MS sensitivity across a broad m/z range, supporting confident detection of low‑abundance species.
- Combined MALDI XS and DESI XS capabilities enable complementary surface and spatially resolved analyses, while ion mobility reduces spectral overlap to improve molecular specificity in complex imaging and profiling workflows.
- Intuitive software supports method development, acquisition, and interpretation, accelerating the path from data to insight.
Recommended Use: Differentiate metabolites, resolve isomers, reduce interference, and confidently characterize complex biological samples using ion mobility.
Structure: revealed, not inferred
Advance native MS with confidence. Interrogate intact protein structure with clarity and control, combining mass selection with high‑resolution cyclic ion mobility to resolve conformational heterogeneity and distinguish multiple structural states within intact proteins and assemblies.
Improve spectral clarity with Dynamic Field Declustering (DFD), which enhances desolvation and reduces adducting to deliver cleaner, more interpretable spectra. Increase sensitivity for low-abundance species using Wideband Enhancement (WBE), improving MS/MS sensitivity for native top‑down experiments and confident characterization of low‑level components. Extend analysis to larger, more challenging assemblies with extended mass range capability supporting transmission and detection of very high mass, low charge ions, expanding native MS to larger and more complex systems.
Deeper insight across structure, stability, and dynamics
Gain deeper structural insight through fragmentation. Complementary dissociation strategies, including ECD and SID, enable interrogation of sequence, higher order structure, and interaction sites, building richer evidence through complementary fragmentation pathways, reducing spectral complexity with mobility‑enabled precursor and product ion selection, and strengthening assignments by separating overlapping product ion populations.
Characterize stability with efficiency through streamlined collision‑induced unfolding (CIU), supporting sensitive, reproducible stability assessment and enabling faster profiling of conformational changes across conditions. Probe dynamics with confidence using integrated HDX workflows that deliver reproducible insight into protein dynamics and flexibility, where mobility‑resolved analysis clarifies overlapping peptide populations and new DynamX 4.0 Software streamlines processing and comparison for faster, higher‑confidence studies.
Visualization that’s resolved, not ambiguous
Confident molecular imaging requires clear differentiation of closely related species in complex tissues. The Waters Cyclic IMS P20 Mass Spectrometer enables separation of isobaric and isomeric ions prior to visualization, delivering stronger molecular confidence and clearer spatial insight.
By combining MALDI XS and DESI XS workflows with multipass cyclic ion mobility and IMSⁿ, the system resolves subtle compositional differences while expanding molecular coverage. High-resolution separation improves specificity in lipid and small molecule analysis, even in complex matrices.
With Wideband enhancement (WBE) for increased sensitivity, Cyclic IMS P20 Mass Spectrometer supports detection of low-abundance species, enabling richer molecular images and more reliable biological interpretation.
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