Extraction+ Connected Device
Simplify SPE methods for easier execution, scalability, and confident reproducibility
Extraction+ delivers reliable solid-phase extraction with automated pressure control and labware handling. When used with Andrew+ and OneLab Software , it minimizes variability and frees up walkaway time for plate and cartridge SPE.
· Automated SPE: Easily run extraction workflows with Andrew+ and OneLab Software.
· Programmable pressure: Set vacuum profiles for consistent results.
· Flexible format support: Works with SPE plates, 1 cc/3 cc/6 cc cartridges, spin columns, SPE tips, and more.
· Data traceability: OneLab Software records steps and parameters for reproducible methods.
Extraction+ Connected Device
Specifications
Overview
- Centralize all your SPE methods in one place with an automated SPE system
- Achieve maximum SPE method repeatability with minimum effort
- Securely share highly detailed methods through OneLab Software
- Eliminate the need to recalibrate your devices each time before every run
- Scale laboratory workflows without any added complexity
- Trigger your connected devices in real-time during method executions
- Ensure confident reproducible results and full traceable executions
Recommended Use: Standardize SPE methods by ensuring reproducible extraction results in real-time through connected devices.
Extraction+ Device Kits
-
3 mm Collection Plate Spacer -
15 mm Collection Plate Spacer
-
17 mm Collection Plate Spacer
-
Adhesive Plate Seal - Samples (x5)
-
Storage Plate Domino
-
Deepwell Microplate Domino
-
1 cc Cartridge Adaptor for Extraction+ Device
-
⌀12mm Vial Collection Rack
-
Pack of 1 cc Sealing Caps (x24)
-
Collection Rack Domino
-
3 cc Cartridge Adaptor for Extraction+ Device
-
⌀12mm Vial Collection Rack
-
Pack of 3 cc Sealing Caps (x24)
-
Adhesive Plate Seal - Samples (x5)
-
Collection Rack Domino
-
6 cc Cartridge Adaptor for Extraction+ Device
-
5mL Tube Collection Rack
-
Pack of 6 cc Sealing Caps (x12)
-
Collection Rack Domino
Redefine SPE with programmable pressure profiles
Programmable vacuum profiles for reliable extractions
Real-time pressure profile control is critical to successful extraction methods. Extraction+ enables software-defined vacuum ramps/holds so protocols run consistently without manual, on-device intervention.
“Replace manual manifold guesswork with repeatable, method-defined vacuum control.”
Built for automation—walkaway SPE
Automated labware movements for true walkaway SPE
After pipetting into extraction labware and initiating the Extraction+ vacuum pump, the Andrew+ robot can move the manifold collar between idle and active positions, enabling automated exchange of waste and collection labware. For continuous waste flow-through, the manifold supports routing to a bottle when appropriate.
Choose your configuration (kits)
Configure Extraction+ for plates or cartridges
Labware flexibility shouldn’t block automation. Choose the kit that matches your SPE format and collection preferences.
OneLab Software ecosystem + method transfer
SPE control inside the OneLab Software connected ecosystem
Extraction+ integrates into OneLab Software methods so vacuum steps become part of the same end-to-end workflow definition and execution. This supports standardization and transferability across users and labs.
“Validate workflow logic in OneLab Software, then scale to walkaway automation with Andrew+—without rebuilding the method.”
Applications
- Oligonucleotide Bioanalysis: Extract therapeutic oligonucleotides from complex fluids (plasma, urine) with kits like OligoWorks.
- Protein and Peptide Quantification: Concentrate peptides and remove interferences post-digestion, often paired with ProteinWorks.
- Forensic Toxicology: Isolate drugs of abuse or biomarkers from blood, serum, or urine using Oasis SPE plates.
- Environmental Analysis: Enrich trace contaminants (PFAS, pesticides, mycotoxins) from water and soil samples.
- Lipidomics and Metabolomics: Fractionate and purify biological samples for specific lipids or metabolites.
- Clinical Endocrinology: Extract steroid hormones and vitamin D metabolites from blood samples.
- Toxicology Screening: Efficient drug screening with higher throughput and less solvent than LLE.
- High-Throughput DMPK: Speed up clearance assays, stability studies, and pharmacokinetics in early drug development.
- Therapeutic Drug Monitoring: Clean blood samples rapidly for immediate LC-MS/MS analysis.
Resources
Support
What do you want to do?
Frequently Asked Questions
What are the key benefits of Extraction+?
- Programmable Pressure Profiles — Define precise vacuum ramps and hold steps in OneLab Software; Extraction+ follows the profile exactly every time. No manual, on-device adjustments — eliminating the operator variability that causes inconsistent recoveries across analysts and runs.
- True Walkaway SPE Automation — After pipetting into extraction labware, Andrew+ triggers the vacuum pump, lifts and moves the manifold collar between idle and active positions, and exchanges waste and collection labware — all without user intervention. Saves up to four hours of bench time per sample set.
- Plate and Cartridge Format Flexibility — Supports 96-well SPE plates (macro and µElution), 1 cc, 3 cc, and 6 cc cartridges, spin columns, and SPE tips — all on one device via dedicated add-on kits.
- Full Method Traceability — Every vacuum step, pressure reading, timing, and labware movement is recorded in OneLab Software. Combined with Andrew+ pipetting traceability, you get a complete, auditable digital record supporting GxP compliance.
Which SPE formats does Extraction+ support?
Extraction+ adapts to your labware configuration through dedicated add-on kits:
- Plate Kit — 96-well SPE plates (macro and µElution); includes 3 mm, 15 mm, and 17 mm plate spacers, Deepwell Microplate Domino, and Storage Plate Domino
- 1 cc Cartridge Kit — 1 cc SPE cartridges; includes 1 cc Cartridge Adaptor, 12 mm Vial Collection Rack, and Collection Rack Domino
- 3 cc Cartridge Kit — 3 cc SPE cartridges; includes 3 cc Cartridge Adaptor, 12 mm Vial Collection Rack, and Collection Rack Domino
- 6 cc Cartridge Kit — 6 cc SPE cartridges; includes 6 cc Cartridge Adaptor, 5 mL Tube Collection Rack, and Collection Rack Domino
Plate spacers accommodate various SBS-format collection plates at different heights within the device, maximizing capture while preventing cross-contamination.
Which lab scenarios are ideal for Extraction+?
- Compliance-driven sample preparation — Replace manual vacuum manifolds with a connected device that logs every pressure profile, timing, and labware movement automatically. OneLab Software provides the digital record QA teams and auditors require — without adding manual documentation steps.
- High-throughput bioanalytical SPE — Workflows like DMPK pharmacokinetic studies, forensic toxicology screening, and therapeutic drug monitoring benefit from fully automated SPE that eliminates pipetting errors and ensures consistent recoveries across analysts and batches.
- Manual-to-automation transition — Extraction+ uses the same OneLab Software protocol whether you run semi-automated with Pipette+ or fully automated with Andrew+. Validate your SPE method at the bench today, then scale to walkaway automation tomorrow — same protocol, no re-validation.
What are the traceability, compliance, and integration benefits?
Traceability & Compliance
- Automated logging of every vacuum pressure setpoint, actual pressure, hold duration, ramp event, and labware movement — no manual entries required.
- Digital protocols replace paper-based SPE records with auditable electronic workflows.
- Supports GxP, GLP/GMP, and 21 CFR Part 11 compliance requirements.
- SPE data captured alongside pipetting data (Pipette+ / Andrew+) and temperature data (Peltier+ / Heater-Shaker+) in a single unified digital record for the entire sample preparation workflow.
Software Integration
- OneLab + Empower — Links SPE sample preparation protocols to chromatography workflows. Automates sample information transfer and supports GxP-compliant, 21 CFR Part 11-ready audit trails.
- OneLab + MassLynx — Exports sample lists from OneLab to MassLynx and triggers LC–MS runs, streamlining the handoff from SPE to mass spectrometry analysis.
- OneLab + waters_connect — Enables LC/MS analyses using existing waters_connect methods and instruments, closing the loop from extraction to analytical result in a single traceable workflow.
These integrations ensure that SPE preparation steps are seamlessly linked to downstream analytical execution with full traceability — eliminating the documentation gap where compliance and data-integrity risks typically occur.
