• Note d'application

Naltrexone in Plasma

Naltrexone in Plasma
  • Waters Corporation
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This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief demonstrates analysis of naltrexone in plasma.

Introduction

The compounds analyzed in this study are - 

  1. Naloxone (I.S.)
  2. Naltrexone

Experimental

HPLC Method

Column:

Symmetry Shield RP8, 3.9 x 150 mm, 5 μm

Part number:

WAT200655

Mobile phase:

100 mM Ammonium acetate pH 5/acetonitrile 88:12

Flow rate:

1.0 mL/min

Injection volume:

1 mL spiked plasma with naloxone (I.S.)

Temperature:

8 °C

Detection:

UV @ 281 nm

Results and Discussion

Chromatogram of Plasma Extracts: A) Blank B) Spiked Sample

Chromatogram of Plasma Extracts: A) Blank B) Spiked Sample.

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WA31763.107, June 2003

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