• Application Note

Sulfa Drugs

Sulfa Drugs
  • Waters Corporation
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Capsule pills in hand with water in glass

This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief demonstrates analysis of sulfa drugs.

Introduction

The compounds used in this study are -

Compounds

USP Tailing Factors

Sulfanilamide

1.27

Sulfadiazine

1.19

Sulfathiazole

1.18

Sulfamerazine

1.15

Sulfamethazine

1.12

Succinylsulfathiazole

1.11

Experimental

HPLC Method

Column:

Symmetry C8, 3.9 x 150 mm, 5 μm

Guard column:

Sentry Guard Column 3.9 x 20 mm, 5 μm

Part numbers:

Column - WAT046970, Guard - WAT054250

Mobile phase:

Water/methanol/glacial acetic acid 79:20:1

Flow rate:

1.0 mL/min

Injection volume:

10 μL of sample with components at 10 to 39 μg/mL

Detection:

UV @ 254 nm

Results and Discussion

Featured Products

WA31763.154, June 2003

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