LC-MRM Quantification of Hamster Phospholipase B-Like 2 Protein (PLBL2) in Therapeutic Monoclonal Antibodies at Part-per-Billion (ppb) Levels

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Gordon Murray, Catalin Doneanu, Ying Qing Yu, and Weibin Chen
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Application Notes
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Application Notes
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In this application note an LC-MRM assay is developed for flexible, high-throughput, sub-ppm quantification assays of multiple HCPs across multiple preparations of biopharmaceuticals.

Compared with the traditional process-specific ELISA assays used for quantification of individual host cell proteins (HCPs), the LC-MRM assays achieve similar sensitivities while they are much more flexible, faster and cheaper to develop.

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