Targeted Metabolomics Using the UPLC/MS-based AbsoluteIDQ p180 Kit

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Evagelia C Laiakis, Albert J Fornace Jr, Ralf Bogumil, Cornelia Roehring, Michael Daxboeck, Marc Bret, Steven Lai, John Shockcor, Steven Cohen, James Langridge, Giuseppe Astarita
Waters, BIOCRATES Life Sciences AG, Georgetown University
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Metabolite Identification

By combining the ACQUITY UPLC System with the Xevo TQ or Xevo TQ-S Mass Spectrometers and the commercially available AbsoluteIDQ p180 Kit, rapid indentification and quantification of more than 180 metabolites in murine serum were successfully attained. Similar applications could lead to novel mechanistic insight and biomarker discovery in drug development, diagnostics, and systems biology research.

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