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UPLC-FLR Method Development of 2-AB Labeled Glycan Separation in Hydrophilic Interaction Chromatography (HILIC)

Library Number:
APNT10151159
Part Number:
720003238en
Author(s):
Joomi Ahn, Ying Qing Yu, and Martin Gilar
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
 
 

Monoclonal antibody (mAB) drug development is an active area in biotherapeutic research. Hydrophilic interaction chromatography (HILIC) with fluorescence detection is one approach to profile glycosylation patterns in recombinant mAbs. As shown in this application note, the Waters ACQUITY UPLC/FLR System used with Glycan Separation Technology Columns achieves highly-resolved glycan separations. This provides significant benefits to high-throughput glycosylation monitoring and profiling.


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