(DIOXIN 2017) 37th International Symposium on Halogenated Persistent Organic Pollutants

  • Sumario
Fecha(s): 20 de agosto de 2017 - 25 de agosto de 2017
Lugar: Vancouver, Canada
Idioma: English

37th International Symposium on Halogenated Persistent Organic Pollutants - DIOXIN 2017

Waters is proud to be a Gold Level Sponsor of DIOXIN 2017

You are invited to stop by booth #17 to learn how Waters' leading analytical technologies can enhance your lab capabilities.


Lunch Seminar
Date: Thursday, 24 August
Time: 12:00 pm - 1:00 pm
Location: Sheraton Vancouver Wall Centre Hotel  
Register now for our lunch seminar

 Denina Simmons

Cryogenic zone compression to enhance sensitivity in non-targeted mass spectrometry to detect trace levels of POPs
Presented by: Denina Simmons, McMaster University, Department of Chemistry, Hamilton, ON, CANADA


In the past, measuring toxic organic contaminants in blood on a wide scale level has presented a challenge due to concentrations that are near-to or below detection limits. Targeted MRM assays could overcome many of those challenges, but is only feasible for a limited number of targets in a single analysis. Targeted analyses are useful when you know what you are looking for, but for scenarios where exposure is unknown, or where previously unidentified contaminants could be present, it may be more useful to identify non-target contaminants. To identify non-target contaminants, full-scan acquisitions using mass spectrometers with high enough resolving power to identify non-target contaminants would be more useful. Full scan acquisitions can sometimes sacrifice sensitivity in order to capture additional spectral information. To address this, we have developed a method to enhance sensitivity using zone compression. In this talk, we present up to 10x signal enhancement using cryogenic modulation during a GC separation paired to the Xevo G2-XS QTof Quadrupole Time-of-Flight Mass Spectrometer with an APGC ion source (Waters). A workflow using Waters UNIFIsoftware to identify non-targeted contaminants was created and validated using dust samples and standards. The methods presented will demonstrate the real potential for non-targeted screening of toxic organic contaminants in humans and wildlife.

Pierre Dumas

An Exposomics study of Canadian native populations utilizing Atmospheric GC coupled with HRMS
Presented by: Pierre Dumas, Institut National de Santé Publique du Québec (INSPQ), Québec, QC, CANADA

  The presented study focuses on the analysis of plasma samples that were obtained from native populations and extracted to analyze persistent organic pollutants (POPs). Samples were analyzed on the APGC couple with the XEVO G2-XS QTof operated in a data independent mode which produced precursor and product ion information in a single acquisition. Data was first subjected to a targeted data analysis to assess the presence of ubiquitous POPs or suspected emerging ones in the samples and to assess the distinctive trends among the different communities of native populations. Following this targeted approach, a non-targeted, multivariate technique was used to identify compounds that were prominent in each community. These compounds were then subjected to database searches in order to identify these markers of interest. Proposed identifications from both targeted and non-targeted approaches will be presented.



Tuesday from 11:20 - 11:40
Session: T1-5
“New Methods of Analysis”

Comprehensive targeted and non-targeted analysis of various indoor dust samples using LC-HRMS with Ion Mobility
Lauren Mullin, Waters Corp.

Monday from 10:40 am - 11:00 am
Session: M1-3 titled
“New and Alternate Instrumental Methods of Analysis”

Comparison of atmospheric pressure chemical ionisation and electron ionisation for the analysis of persistent organic pollutants
Rhys Jones, Waters Corp.

Thursday from 3:05 - 3:35
"Analysis of emerging and legacy persistent organic contaminants"

Method Development of a 2–Dimensional Liquid Chromatography High Resolution Mass Spectrometry Method for The Analysis of Organophosphorus Flame Retardants in Water Samples
Lauren Mullin, Waters Corp.