ACQUITY UPLC I-Class / Xevo TQ-S IVD System

Class leading sensitivity and robustness for maximum uptime in the clinical laboratory

The innovative StepWave ion guide, delivers the highest levels of sensitivity and robustness. The Xevo TQ-S enables the lowest detection limits to be achieved for the most challenging analytes in the most challenging of clinical specimens. Instrument performance is maintained using the innovative active separation of ions from neutrals care of advanced T-Wave technology.

Yes, quantitative and qualitative information from the same sample in the same run!

With its unique collision cell, Xevo TQ-S enables you to better address your analytical needs with the option to operate in ScanWave enhanced product ion scanning mode. This mode enables you to more easily confirm the identities and structures of your analytes of interest, at the low concentrations required. What’s more, this is done whilst retaining all of the capabilities of the standard T-Wave collision cell. This ensures the very best MRM quantification data for your demanding, high speed, and high resolution LC-MS/MS assays.

Understanding sample complexity

Some challenges for quantitative methods are:

• Calculating compound concentrations in addition to the detection of unexpected contaminants.
• Characterisation of the background matrix for every sample, increasing data quality.
• Detection of analytes that are not in a targeted multiple reaction monitoring (MRM) screening method.
• Improving method development by discovering more matrix components.

These challenges may be overcome by using RADAR which is the ability to obtain full scan (MS) and MRM (MS-MS) data simultaneously.

Product Ion Confirmation scanning (PICS) allows you to have full confidence in your results. Activated by a single check box in the method editor, PICS automatically triggers a product ion scan when a peak is detected by MRM.