The analysis of immunosuppressant drugs tacrolimus, cyclosporin, serolimus, and everolimus with LC-MS/MS has been widely accepted as the gold standard for clinical research laboratories. The ACQUITY UPLC I-Class PLUS and Xevo TQD mass spectrometer minimize interferences from cross reactivity and inaccuracies due to hematocrit variability for clinical research into additional applications.
The research of tacrolimus, cyclosporine, serolimus, and everolimus in whole blood with immunoassay is susceptible to cross creativity giving way to potential varying concentrations. The UPLC I-Class Xevo TQD allows for greater specificity through the minimization of interfering compounds with enhanced sensitivity.