5-Fluorouracil analysis with quantitative UPLC-MS/MS for clinical research

5-Fluorouracil is used as an anti-cancer agent, inhibiting the formation of DNA and to a lesser extent RNA. Clinical researchers continue to investigate the effects of the drug. Since there is a high degree of inter-individual variability for its metabolism, an analytically sensitive and selective measurement procedure may aid in pharmacokinetic and pharmacodynamic clinical research studies. The ACQUITY UPLC I-Class PLUS used with the Xevo TQD mass spectrometer provides the sensitivity and selectivity needed for greater accuracy.