Researching the pharmacokinetic and pharmacodynamic effects caused by the administration of 5-fluorouracil requires an analytical technique with great specificity and sensitivity due to the variation in its metabolism. The ACQUITY UPLC I-Class PLUS System and Xevo TQD Mass Spectrometer offer such selectivity and sensitivity to provide an accurate result when researching clinical samples.
5-Fluorouracil is used as an anti-cancer agent, inhibiting the formation of DNA and to a lesser extent RNA. Clinical researchers continue to investigate the effects of the drug. Since there is a high degree of inter-individual variability for its metabolism, an analytically sensitive and selective measurement procedure may aid in pharmacokinetic and pharmacodynamic clinical research studies. The ACQUITY UPLC I-Class PLUS used with the Xevo TQD mass spectrometer provides the sensitivity and selectivity needed for greater accuracy.