Literature


Results for upc2
Description
A Green and Comprehensive Approach for Palm Phytonutrients Analysis Using ACQUITY UltraPerformance C...
Library Number: APNT135082067 | Format: PDF | File Size: 522.67 kB | Year: 2021 | Content Type: Application Notes

In this study, we developed a green alternative, more efficient separation method with Waters’ ACQUITY UltraPerformance Convergence Chromatography (UPC2) technology using supercritical CO2 as mobile phase for the analysis of vitamin E, phytosterols, and s...

Differentiation of Natural Vitamin E from Synthetic Vitamin E for Food and Dietary Supplement Nutrit...
Library Number: APNT135072984 | Format: PDF | File Size: 357.87 kB | Year: 2020 | Content Type: Application Notes

This application brief demonstrates the capability of Waters ACQUITY UPC2 system and Trefoil columns for the differentiation between natural and synthetic vitamin E.

Operating Parameter Effects on the Separation of Carotenoids and Coenzyme Q10 by UltraPerformance Co...
Library Number: APNT135024251 | Format: PDF | File Size: 699.21 kB | Year: 2019 | Content Type: Application Notes

A fast UPC2 method to separate lycopene, beta-carotene, lutein and coenzyme Q10 is described.

A Comparative Study of Electrospray and UniSpray Sources Using ACQUITY UPC2
Library Number: APNT134982707 | Format: PDF | File Size: 429.9 kB | Year: 2018 | Content Type: Application Notes

This application note discusses a comparative study between the ESI and UniSpray sources coupled to ACQUITY UPC2.

Qualitative and Quantitative Analysis of Gentamicin Sulfate and Related Impurities on ACQUITY UPLC w...
Library Number: APNT135024044 | Format: PDF | File Size: 1064.09 kB | Year: 2019 | Content Type: Application Notes

Effective method development for the qualitative and quantitative analysis of gentamicin sulfate and related impurities.

The Effects of SFC Preparative Scale-up on Throughput, Purity, and Recovery of an Impurity in an API...
Library Number: APNT135005814 | Format: PDF | File Size: 465.59 kB | Year: 2018 | Content Type: Application Notes

A Chromatographic method development was performed at analytical scale using ACQUITY UPC2 to separate the API from the impurities.

Essential Oil Metabolomic Profiling with HRMS and a Variety of Complementary Ionization Techniques -...
Library Number: APNT135013329 | Format: PDF | File Size: 1441.22 kB | Year: 2019 | Content Type: Application Notes

This study enabled the analysis of LC-MS data generated from a multitude of analyses of vetiver essential oil in a quick and easy way.

Improving the Analysis of Triazole Fungicides in Wheat Straw Samples using UniSpray Ionization with ...
Library Number: APNT134907752 | Format: PDF | File Size: 754.25 kB | Year: 2016 | Content Type: Application Notes

This technology brief, evaluates the potential of Waters UniSpray source coupled with the ACQUITY UPC2 System and Xevo TQ-XS Mass Spectrometer versus ESI to improve peak response, repeatability and signal-to-noise for the analysis of triazole fungicides. ...

ACQUITY UPC2 Food Application Notebook
Library Number: APNT134840282 | Format: PDF | File Size: 7356.04 kB | Year: 2015 | Content Type: Application Notes

UPC2 enables food scientists to separate, detect, and quantify a broad range of compounds, including fat-soluble vitamins, lipids and fatty acids, structural analogs and isomers, in complex matrices with unequaled speed and confidence.

Fatty Acid Profiling by UPC2-MS
Library Number: APNT134902890 | Format: PDF | File Size: 926.98 kB | Year: 2016 | Content Type: Application Notes

In this technology brief, we describe a fast and simple approach for the profiling of fatty acids in food.

The Use of ACQUITY UPC2 and the Waters SFC Investigator System for the Analysis, Separation, and Iso...
Library Number: APNT134957068 | Format: PDF | File Size: 1720.37 kB | Year: 2017 | Content Type: Application Notes

This application note demonstrates the separation, purification, and subsequent identification of Canagliflozin and its isomeric impurities.

Analysis of Nucleosides by UltraPerformance Convergence Chromatography (UPC2)
Library Number: APNT134855713 | Format: PDF | File Size: 801.63 kB | Year: 2015 | Content Type: Application Notes

This technology brief demonstrates the advantages of utilizing UltraPerformance Convergence Chromatography™ (UPC2®) to address the analysis of highly polar compounds.

Analysis of Antidiabetic Drug Canagliflozin and Related Isomeric Impurities Using the ACQUITY UPC2 S...
Library Number: APNT134961702 | Format: PDF | File Size: 729.95 kB | Year: 2017 | Content Type: Application Notes

This application note demonstrates the separation of Canagliflozin and its isomeric impurities.

The Separation of Δ8-THC, Δ9-THC, and Their Enantiomers by UPC2 Using Trefoil Chiral Columns
Library Number: APNT134913656 | Format: PDF | File Size: 789.78 kB | Year: 2016 | Content Type: Application Notes

The separation of THC and their enantiomers is determined using Acquity UPC2 system.

Exploiting the Orthogonality of the ACQUITY UPC2 System to Develop an Impurities Method for Ondanset...
Library Number: APNT134903247 | Format: PDF | File Size: 254.84 kB | Year: 2016 | Content Type: Application Notes

This application note describes retention of small polar compounds using UPC2 and simplified method development using ACQUITY QDa.

Quantitative Method for the Determination of Potentially Mutagenic Impurities of Ondansetron Using U...
Library Number: APNT134927810 | Format: PDF | File Size: 255.71 kB | Year: 2017 | Content Type: Application Notes

In this study, two polar impurities were easily retained and separated from the API using SFC.

The Direct Quantification of a Mutagenic Impurity, Methyl Amino Crotonate, Using ACQUITY UPC2 and QD...
Library Number: APNT134919219 | Format: PDF | File Size: 333.42 kB | Year: 2016 | Content Type: Application Notes

The analysis of MAC (Methyl-3-aminocrotonate) is studied in this application note.

Effects of Aqueous Sample Content and Aqueous Co-Solvent Composition on UPC2 Separation Performance
Library Number: APNT134864458 | Format: PDF | File Size: 1248.91 kB | Year: 2015 | Content Type: Application Notes

Here we demonstrate the application of UPC2 for the analysis of polar analytes in aqueous matrices.

Impurity Profiling Using UPC2/MS
Library Number: APNT134722956 | Format: PDF | File Size: 1637.12 kB | Year: 2013 | Content Type: Application Notes

Utilizing UPC2/MS increased the knowledge base of pharmaceutical product quality, and improved the methodology procedures involved with achieving the analytical goals.

Optimization of Chromatographic Conditions for the Analysis of Polar Metabolites in Aqueous Solution...
Library Number: APNT134864453 | Format: PDF | File Size: 1194.87 kB | Year: 2015 | Content Type: Application Notes

This application note evaluates the effects that the UPC2 method parameters, such as column chemistry, mobile phase gradient conditions, and eluent solvent composition have on the chromatographic analysis of biologically relevant polar analytes in aqueous...

UPC2 Method Development for Achiral Impurity Analysis
Library Number: APNT134722246 | Format: PDF | File Size: 2188.82 kB | Year: 2013 | Content Type: Application Notes

An achiral analysis of metoclopramide and related substances was successfully performed using the ACQUITY UPC2 System.

Lipid Class Separation Using UPC2/MS
Library Number: APNT134722800 | Format: PDF | File Size: 1955.77 kB | Year: 2013 | Content Type: Application Notes

A flexible, universal method was developed for the analysis of inter-class separations of neutral and amphipathetic lipids. The organic phase of the biological lipid extract can be directly injected onto the ACQUITY UPC2 System with MS detection, thereby ...

Enantioseparation of Metalaxyl Using ACQUITY UPC2 and Small-Scale Purification Using the Investigato...
Library Number: APNT134832282 | Format: PDF | File Size: 1723.39 kB | Year: 2015 | Content Type: Application Notes

In this application note, we present the chiral resolution of metalaxyl using the ACQUITY UPC2 System, followed by scaling to a semi-preparative purification using the Investigator SFC System.

Chiral Separation of Clenbuterol Using UPC2
Library Number: APNT134720442 | Format: PDF | File Size: 196.89 kB | Year: 2012 | Content Type: Application Notes

Using UPC2 with smaller particle columns, a rapid method for chiral analysis of clenbuterol was developed. The analysis was completed in less than three minutes, allowing for high throughput analysis. The method was also reproducible over several injectio...

Application of UPC2 in Extractables Analysis
Library Number: APNT134714225 | Format: PDF | File Size: 2478.6 kB | Year: 2012 | Content Type: Application Notes

Four different types of packaging material were extracted and screened for 14 common polymer additives. The UPC2 analysis was compared to GC and UPLC chromatographic profiles. The UPC2 analysis provided a two-fold improvement in run time compared to UPLC,...