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Best Practices for Oligonucleotide Analysis Using Ion-Pair Reversed-Phase (IP-RP) Liquid Chromatogra...
Библиотечный номер: APNT135071755 | Формат: PDF | Размер файла: 1177.92 kB | Год: 2020 | Тип содержания: Методики

In this application brief, Waters provides a short list of best practices to characterize oligonucleotides by ion-pair reversed-phase (IP-RP) liquid chromatography. These best practices cover separation temperature, pH optimization, pore size selection, m...

Best Practices for Maintaining Column Performance in Size-Exclusion Chromatography during Long-Term ...
Библиотечный номер: APNT135078695 | Формат: PDF | Размер файла: 440.75 kB | Год: 2020 | Тип содержания: Методики

This application note investigates long-term Size-Exclusion Chromatography (SEC) column storage solvents using BioResolve SEC mAb Columns and the Waters mAb Size Variant Standard.

Quantifying Primary Aromatic Amines in Polyamide Kitchenware Using the ACQUITY UPLC I-Class System a...
Библиотечный номер: APNT134909760 | Формат: PDF | Размер файла: 556.42 kB | Год: 2020 | Тип содержания: Методики

In this application note we describe a LC-MS/MS method for the analysis of 23 common PAAs in kitchenware after migration using the ACQUITY UPLC I-Class System coupled to a Xevo TQ-S micro Mass Spectrometer.

UPLC Analysis of Benzalkonium Chloride (BAC) in Consumer Products using ACQUITY UPLC CSH C18
Библиотечный номер: APNT134730079 | Формат: PDF | Размер файла: 3199.58 kB | Год: 2020 | Тип содержания: Методики

This application note describes the accurate determination of benzalkonium chloride (BAC) content in consumer products.

Application of a Mass Confirmation Workflow for Biotherapeutics Screening
Библиотечный номер: APNT135075434 | Формат: PDF | Размер файла: 1124.85 kB | Год: 2020 | Тип содержания: Методики

In this study, we report the development of a high throughput intact mass confirmation workflow using the BioAccord LC-MS System operated under the control of waters_connect informatics.

Determination of Haloacetic Acids and Acrylamide in Drinking Water by Direct Injection Using Liquid ...
Библиотечный номер: APNT135078336 | Формат: PDF | Размер файла: 1023.98 kB | Год: 2020 | Тип содержания: Методики

The purpose of this work is to demonstrate a direct injection method for the determination of acrylamide and haloacetic acids in drinking water that exceeds the requirements for the new EU Drinking Water Directive 2020.

Analytical Quality by Design Based Method Development for the Analysis of Valsartan and Nitrosamines...
Библиотечный номер: APNT135078339 | Формат: PDF | Размер файла: 773.78 kB | Год: 2020 | Тип содержания: Методики

In this application note, a software assisted AQbD approach was implemented to develop a method for the analysis of valsartan standard and six genotoxic impurities (NDMA, NMBA, NDEA, NEIPA, NDIPA, and NDBA).

Quantification of Human Papillomavirus (HPV) Antigens in the Nonavalent Vaccine GARDASIL 9
Библиотечный номер: APNT135078342 | Формат: PDF | Размер файла: 710.28 kB | Год: 2020 | Тип содержания: Методики

A mass spectrometry assay for the simultaneous quantification of HPV L1 protein antigens in Gardasil 9 was developed.

Seized Drug Screening using the ACQUITY RDa Detector
Библиотечный номер: APNT135078345 | Формат: PDF | Размер файла: 1111.91 kB | Год: 2020 | Тип содержания: Методики

This application note details the use of Waters' new ACQUITY RDa Detector for seized drug screening with a ten minute analysis time utilizing a dissolve, filter, dilute, and shoot sample preparation.

Increasing Chromatographic Performance of Acidic Peptides in RPLC-MS-based Assays with ACQUITY PREMI...
Библиотечный номер: APNT135075223 | Формат: PDF | Размер файла: 928.05 kB | Год: 2020 | Тип содержания: Методики

In this study, the performance gain of ACQUITY PREMIER Columns with MaxPeak HPS Technology is demonstrated with increased recovery, reproducibility, and robustness of RPLC-MS-based peptide mapping assays using the Waters NIST mAb tryptic digest standard.

Comprehending COVID-19: Structural Characterization of the Glycan Assemblies of O-linked Glycopeptid...
Библиотечный номер: APNT135078200 | Формат: PDF | Размер файла: 777.69 kB | Год: 2020 | Тип содержания: Методики

This application exploits Waters SELECT SERIES Cyclic IMS instrument for the characterization of the glycan structures and linkages of O-linked glycopeptides.

Repeatability of the ACQUITY UPLC H-Class PLUS Bio Binary System Under Challenging Separation Condit...
Библиотечный номер: APNT135078149 | Формат: PDF | Размер файла: 380.33 kB | Год: 2020 | Тип содержания: Методики

This application brief evaluates peptide mapping results collected on a biocompatible binary LC system over 24 hours and compares results over three days.

Determination of Aromatic Hydrocarbon Types in Middle Distillates with the Alliance HPLC System and ...
Библиотечный номер: APNT135078152 | Формат: PDF | Размер файла: 421.06 kB | Год: 2020 | Тип содержания: Методики

This application brief highlights the use of the Waters Alliance HPLC System coupled to the Waters 2414 Refractive Index Detector to determine mono-, di-, tri+-, and polycyclic aromatic hydrocarbon contents in diesel fuels and petroleum distillates in com...

DART-QDa for the Rapid Differentiation of Curcuma longa and Curcuma xanthorrhiza in Adulterated Spic...
Библиотечный номер: APNT135077703 | Формат: PDF | Размер файла: 672.94 kB | Год: 2020 | Тип содержания: Методики

This application note describes the use of Waters DART QDa System with Live ID to successfully differentiate between seemingly identical samples of turmeric spice based on differing levels of high value antioxidant anti-inflammatory chemoprotective active...

Comprehending COVID-19: Application of UniSpray and Electrospray Ionization for the Detection of Pro...
Библиотечный номер: APNT135077658 | Формат: PDF | Размер файла: 344.93 kB | Год: 2020 | Тип содержания: Методики

The work presented here demonstrates the application of UniSpray and Electrospray ionization sources for the detection of selected SARS-CoV-2 tryptic peptides with a Xevo TQ-XS Tandem Quadrupole Mass Spectrometer.

Oasis WAX for Extraction of Per- and Polyfluorinated Alkyl Substances (PFAS) from Drinking Water in ...
Библиотечный номер: APNT135047248 | Формат: PDF | Размер файла: 396.53 kB | Год: 2020 | Тип содержания: Методики

This application brief demonstrates the extraction of PFAS from drinking water samples using the Waters Oasis WAX for PFAS Analysis Cartridge as an equivalent SPE chemistry for the methodology described in EPA method 533.

Reliable and Robust Injector Precision and Linearity with the Arc HPLC System
Библиотечный номер: APNT135077577 | Формат: PDF | Размер файла: 629.62 kB | Год: 2020 | Тип содержания: Методики

The work presented here demonstrates that the new Arc HPLC System delivers linear and highly reproducible sample injections across the range of analytical HPLC injection volumes even when the sample diluent is 100% organic.

Comprehending COVID-19: Using the Atlantis PREMIER BEH C18 AX Mixed-Mode Column for the Analysis of ...
Библиотечный номер: APNT135075018 | Формат: PDF | Размер файла: 337.24 kB | Год: 2020 | Тип содержания: Методики

This application note demonstrates that sharper peaks can be achieved for umifenovir through the use of a mixed-mode stationary phase versus a more conventional reversed-phase material.

Rapid Analysis of Antioxidants in Synthetic Lubricants
Библиотечный номер: APNT10129778 | Формат: PDF | Размер файла: 585.41 kB | Год: 2009 | Тип содержания: Методики

This application note illustrates a rapid analysis of phenolic and diphenylamine antioxidants in synthetic lubricants.

Comprehending COVID-19: Preliminary Examination of the SARS-CoV-2 Spike Protein by Peptide Mapping
Библиотечный номер: APNT135071693 | Формат: PDF | Размер файла: 744.32 kB | Год: 2020 | Тип содержания: Методики

In this app brief, we apply a tryptic peptide mapping approach to analyze a recombinant SARS-CoV-2 spike protein using a BioAccord LC-MS system.

Increased Resolving Power for Acidic Glycans with an MS-Compatible Anion Exchange Reversed Phase Sep...
Библиотечный номер: APNT135076530 | Формат: PDF | Размер файла: 584.95 kB | Год: 2020 | Тип содержания: Методики

A novel mixed-mode, anion-exchange RPLC stationary phase has been used to afford a class separation of different charge states and additional resolution of acidic glycans.

Peptide Mapping using Binary Biocompatible LC Systems: Evaluation of Retention Time Precision and Mi...
Библиотечный номер: APNT135077474 | Формат: PDF | Размер файла: 493.97 kB | Год: 2020 | Тип содержания: Методики

This application note demonstrates a high level of reproducibility, which is a critical attribute of reliable and accurate data.

Revolutionizing SPE with Otto SPEcialist: An Easy-to-Use, Software-Driven, Positive Pressure Manifol...
Библиотечный номер: APNT135077477 | Формат: PDF | Размер файла: 746.65 kB | Год: 2020 | Тип содержания: Методики

This work encapsulates the reliability that this new and seamless technology can provide when executing a solid-phase extraction method using the Otto SPEcialist Positive Pressure Manifold.

Comprehending COVID-19: Reversed-Phase Liquid Chromatography (RPLC) of Intact SARS-CoV-2 Spike Prote...
Библиотечный номер: APNT135071700 | Формат: PDF | Размер файла: 422.29 kB | Год: 2020 | Тип содержания: Методики

This application brief focuses on reversed-phase liquid chromatographic analysis of the intact SARS-CoV-2 spike protein which has emerged as a potential target for vaccine development due to its role in viral pathogenesis.

Instrument Mixer Considerations to Improve Assay Reproducibility and Sensitivity
Библиотечный номер: APNT135077382 | Формат: PDF | Размер файла: 279.68 kB | Год: 2020 | Тип содержания: Методики

This work demonstrates the advantages of using the Waters 340 µL biocompatible mixer to optimize chromatographic performance and detector response with minimal change to instrument configuration.