Literature


Description
Evaluation of Multivariate Calibration with RADIAN ASAP Data for the Quantitation of Edible Oil Blen...
Library Number: APNT135091010 | Format: PDF | File Size: 519.11 kB | Year: 2021 | Content Type: Application Notes

This application notes demonstrate the Blending of edible oils can improve the functional properties, stability, and sensory characteristics for the manufacturing of food products. In addition, adulteration of high-quality edible oils with cheap alternati...

LC-MS Bioanalytical Quantification of a GalNAc-siRNA Conjugate Oligonucleotide Using Semi-Automated ...
Library Number: APNT135090946 | Format: PDF | File Size: 785.04 kB | Year: 2021 | Content Type: Application Notes

This app note demonstrates the the capabilities of the Pipette+ in combination with the Otto SPEcialist for semi-automated liquid handling and solid phase extraction (SPE) of a GalNAc-siRNA conjugated oligonucleotide.

Routine Determination of Per- and Polyfluoronated Alkyl Substances (PFAS) in Drinking Water by Direc...
Library Number: APNT135090959 | Format: PDF | File Size: 1103.08 kB | Year: 2021 | Content Type: Application Notes

This application notes demonstrate a direct injection UPLC-MS/MS method for the determination of PFAS compounds in drinking water in response to the parametric level requirements in the 2020 recast EU Drinking Water Directive.1 The method performance stud...

Determination of Fatty Acids Composition in Polysorbate 20 Pharmaceutical Raw Material Using HPLC wi...
Library Number: APNT135087356 | Format: PDF | File Size: 744.22 kB | Year: 2021 | Content Type: Application Notes

This application note details about a fast HPLC method with mass detection for polysorbate 20 analysis based on free fatty acids composition.

Improvements in the Chromatographic Performance of Antiviral Compounds Analyzed with MaxPeak HPS Tec...
Library Number: APNT135090909 | Format: PDF | File Size: 438.96 kB | Year: 2021 | Content Type: Application Notes

In this application note, we compare the chromatographic performance of an XBridge Premier BEH C18 Column to the performance of a conventional XBridge BEH C18 Stainless-Steel Column for the separation of twelve representative antiviral pharmaceutical comp...

Reductions in Cost and Time by Modernizing a USP Monograph Method from HPLC to UHPLC and UPLC Instru...
Library Number: APNT135090912 | Format: PDF | File Size: 492.93 kB | Year: 2021 | Content Type: Application Notes

In this application note, we demonstrate modernization of a USP method for naproxen sodium tablets from HPLC to UHPLC and UPLC technologies.

Exceptional Carryover Performance of the Arc HPLC System for Chlorhexidine Sample
Library Number: APNT135090923 | Format: PDF | File Size: 1099.39 kB | Year: 2021 | Content Type: Application Notes

This app note demonstrates the exceptional carryover performance of Arc HPLC System for Chlorhexidine sample.

HILIC as an Alternative Separation Mode for Intact Mass Confirmation of Oligonucleotides on the BioA...
Library Number: APNT135090878 | Format: PDF | File Size: 1029.14 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates about the BioAccord LC-MS System, which enables waters_connect users to perform rapid and accurate intact mass confirmations for small and medium size oligonucleotides (up to 50-mers).

Separation of Pentose Phosphate Pathway, Glycolysis, and Energy Metabolites Using an ACQUITY Premier...
Library Number: APNT135090564 | Format: PDF | File Size: 1573.07 kB | Year: 2021 | Content Type: Application Notes

This application note describes about, the ACQUITY Premier System and Atlantis Premier BEH Z-HILIC Columns which will be useful for polar metabolomics assays, particularly for metabolites that interact with metal surfaces.

Automated RapiFluor-MS Labeled Glycan Sample Preparation for Disulfide-Rich Glycoprotein
Library Number: APNT135090582 | Format: PDF | File Size: 1299.77 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates N-glycans are routinely monitored for the quality of biotherapeutics because they affect the safety and efficacy of many therapeutic proteins. Current glycan analysis is developed with the well-studied glycans from monoc...

Utilizing the SELECT SERIES Cyclic IMS for High Throughput Plasma Proteomics
Library Number: APNT135090350 | Format: PDF | File Size: 653.79 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates, the use of analytical scale chromatography for the analysis of plasma tryptic digest samples using the SELECT SERIES Cyclic IMS, which have previously been analyzed using an alternative Q-Tof mass spectrometer.

Metrological Traceability of the Waters MassTrak Endocrine Steroid Calibrator and Quality Control Se...
Library Number: APNT135090210 | Format: PDF | File Size: 657.65 kB | Year: 2021 | Content Type: Application Notes

This application brief, provide an overview of the Waters MassTrak Endocrine Steroid Calibrator and Quality Control Sets and their accuracy and comparisons across lot-to-lot testing.

Methods for the Anion Exchange Chromatographic Analysis of mRNAs
Library Number: APNT135089970 | Format: PDF | File Size: 228.6 kB | Year: 2021 | Content Type: Application Notes

In this application note, we demonstrate that using an anion exchange column between 30–50 °C at neutral pH might be suitable for this type of analysis.

Determination of Fatty Acids in Polysorbate 80 Pharmaceutical Raw Materials by HPLC With Mass Detect...
Library Number: APNT135090024 | Format: PDF | File Size: 1388.71 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates about how an HPLC-MS was developed for the determination of fatty acids composition in the polysorbate 80 pharmaceutical raw material by direct analysis of hydrolyzed samples.

Improving Peak Capacity while Maintaining Selectivity using CORTECS Columns on an Agilent 1290 LC Sy...
Library Number: APNT135084109 | Format: PDF | File Size: 615.09 kB | Year: 2021 | Content Type: Application Notes

This application note investigates a separation of six sulfa drugs using a superficially porous CORTECS C18 Column.

Enhanced Performance for Basic Analytes at Low pH Using a CORTECS C18+ Column on an Agilent 1290 LC ...
Library Number: APNT135085324 | Format: PDF | File Size: 457.31 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates the separation of the Reversed-Phase QC Reference Material (RP-QCRM) on two different columns packed with superficially porous particles (SPP) and C18 ligands.

Troubleshooting Common System Problems Using Waters Neutrals Quality Control Reference Material
Library Number: APNT134728656 | Format: PDF | File Size: 2461.86 kB | Year: 2013 | Content Type: Application Notes

In this application, six common chromatographic problems are examined to demonstrate the utility of the Neutrals QCRM in rapidly diagnosing problems on an HPLC or UPLC system.

Separation and Detection of an Azido Impurity in Sartan Drug Substances Using the XSelect CSH Phenyl...
Library Number: APNT135088337 | Format: PDF | File Size: 396 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates UHPLC method with dual UV-MS detection for the quick and accurate, 3-minute analysis of this azido impurity, 5-[4’-(azidomethyl)-[1,1’-biphenyl]-2-yl)-1H-tetrazole, and the sartan APIs irbesartan, lorsartan, and valsarta...

Analysis of Antibiotics in Plasma for Clinical Research
Library Number: APNT135089770 | Format: PDF | File Size: 2214.89 kB | Year: 2021 | Content Type: Application Notes

This application note describes a clinical research method using protein precipitation of a plasma sample with internal standards.

A Novel Phenyl Bonded Phase for Improved Reversed-Phase Separations of Proteins
Library Number: APNT134975214 | Format: PDF | File Size: 1033.4 kB | Year: 2018 | Content Type: Application Notes

This application note demonstrates the benefits of the unique stationary phase of BioResolve RP mAb Polyphenyl Columns.

Confidence in Your Calibrators: MassTrak Endocrine Steroid Calibrators and Quality Control Sets for ...
Library Number: APNT135089662 | Format: PDF | File Size: 1621.29 kB | Year: 2021 | Content Type: Application Notes

The MassTrak Endocrine Steroid Calibrator and Quality Control Sets performance was demonstrated using the ACQUITY UPLC I-Class PLUS and Xevo TQ-S micro Triple Quadrupole Mass Spectrometry and an in-house developed LC-MS/MS methodology.

Migration of an HILIC Method for Released Glycan Analysis from the ACQUITY UPLC H-Class PLUS Bio Sys...
Library Number: APNT135089362 | Format: PDF | File Size: 277.81 kB | Year: 2021 | Content Type: Application Notes

In this application brief, an HILIC method originally developed on the ACQUITY UPLC H-Class PLUS Bio System was migrated to the Arc Premier System to demonstrate the Arc Premier System as a suitable LC platform to support drug development and manufacturin...

SEC/GPC, DSC, and TGA Analysis of Low Molecular Weight Poly-L-lactic Acid
Library Number: APNT135089156 | Format: PDF | File Size: 1792.99 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates the Waters ACQUITY Advanced Polymer Chromatography (APC) System, TA Instruments’ Discovery 2500 Differential Scanning Calorimeter (DSC), and Discovery 5500 Thermogravimetric Analyzer (TGA) in characterizing four samples ...

ACQUITY UPLC I-Class/Xevo TQD IVD System: Analytical Performance for Antibiotics
Library Number: APNT135088992 | Format: PDF | File Size: 603.88 kB | Year: 2021 | Content Type: Application Notes

This document describes a test of the analytical performance of the ACQUITY UPLC I-Class/Xevo TQD IVD System for the analysis of ampicillin, azithromycin, cefazolin, cefepime, cefotaxime, ceftazidime, chloramphenicol, ciprofloxacin, clindamycin, daptomyci...

Case Study: Investigating Unexpected Results of a Global Cross-Laboratory Study of a USP Organic Imp...
Library Number: APNT135088925 | Format: PDF | File Size: 1112.91 kB | Year: 2021 | Content Type: Application Notes

In this application note, a global interlaboratory method transfer of a USP organic impurities method was conducted across eight sites around the world.