Bibliothèque Technique


Descriptif
Détermination du formaldéhyde dans l’air
Référence Documentation: 720001988EN | Format: PDF | Taille du fichier: 616.34 kB | Année: 2007 | Type: Notes d'applications

Détermination du formaldéhyde dans l’air

TRANSPOSITION DU CONTRÔLE USP DE LA SIMVASTATINE EN UPLC
Référence Documentation: 720001901EN | Format: PDF | Taille du fichier: 517.82 kB | Année: 2007 | Type: Notes d'applications

TRANSPOSITION DU CONTRÔLE USP DE LA SIMVASTATINE EN UPLC

Illustration of the Analytical Performance of the Waters MassTrak Endocrine Steroid Calibrators and ...
Référence Documentation: APNT135088548 | Format: PDF | Taille du fichier: 327.96 kB | Année: 2021 | Type: Notes d'applications

This application brief describes a test of the analytical performance of the MassTrak Endocrine Steroid Calibrator and QC Set (IVD) using the Waters ACQUITY I-Class/Xevo TQ-S micro IVD System.

Analysis of siRNA Duplexes at Non-Denaturing UPLC Conditions Using MaxPeak Premier Column Technology
Référence Documentation: APNT135088510 | Format: PDF | Taille du fichier: 441.72 kB | Année: 2021 | Type: Notes d'applications

This application note describes the analysis of formulation comprising of two siRNA duplexes.

Analysis of siRNA Drugs at Denaturing UPLC Conditions Using MaxPeak Premier Column Technology
Référence Documentation: APNT135088513 | Format: PDF | Taille du fichier: 720.21 kB | Année: 2021 | Type: Notes d'applications

This application note demonstrates the utility of ACQUITY Premier Peptide BEH C18, 300 Å Column for analysis of small interfering RNA (siRNA) therapeutic candidate compound.

Analysis of Oligonucleotide Impurities on the BioAccord System with ACQUITY Premier
Référence Documentation: APNT135087944 | Format: PDF | Taille du fichier: 1266.35 kB | Année: 2021 | Type: Notes d'applications

This application note demonstrates an automated, compliance-ready LC-MS workflow for purity analysis and intact mass confirmation of extensively modified oligonucleotides and their impurities.

Separation and Detection of an Azido Impurity in Sartan Drug Substances Using the XSelect CSH Phenyl...
Référence Documentation: APNT135088337 | Format: PDF | Taille du fichier: 396.57 kB | Année: 2021 | Type: Notes d'applications

This application note demonstrates UHPLC method with dual UV-MS detection for the quick and accurate, 3-minute analysis of this azido impurity, 5-[4’-(azidomethyl0[1,1’-biphenyl]-2-yl)-1H-tetrazole, and the sartan APIs irbesartan, lorsartan, and valsartan...

Comprehensive APC 2D Analysis of an Eight Component Polymer Blend
Référence Documentation: APNT135088349 | Format: PDF | Taille du fichier: 395.15 kB | Année: 2021 | Type: Notes d'applications

Separation of a blend consisting of eight components that either have a similar or same chemistry or molecular weight might not be achievable with a single technique. Co-elution of some kind is a common cause when dealing with incomplete separation. The c...

Monitoring Nutrients and Metabolites in Spent Cell Culture Media for Bioprocess Development Using th...
Référence Documentation: APNT135088229 | Format: PDF | Taille du fichier: 1815.91 kB | Année: 2021 | Type: Notes d'applications

This application note describes a detailed reversed phase LC-MS method and a comprehensive workflow for the monitoring of compounds in cell culture media.

Routine Accurate Mass Measurement for the Identification of Impurities in Quetiapine Fumarate API Us...
Référence Documentation: APNT135088243 | Format: PDF | Taille du fichier: 1593.7 kB | Année: 2021 | Type: Notes d'applications

This application note demonstrates a simplified workflow for routine accurate mass measurement for the identification of Quetiapine and its related impurities with the ACQUITY RDa Detector.

Released Glycan Analysis of Erythropoietin Using the ACQUITY Premier Glycan BEH C18 AX Column and Bi...
Référence Documentation: APNT135087950 | Format: PDF | Taille du fichier: 724.81 kB | Année: 2021 | Type: Notes d'applications

This application note evaluates a method developed using the ACQUITY Premier C18 AX Column and its ability to analyze RFMS-labeled sialylated structures.

Lipid Nanoparticle Compositional Analysis Using Charged Surface Hybrid Phenyl-Hexyl Separation With ...
Référence Documentation: APNT135087972 | Format: PDF | Taille du fichier: 409.5 kB | Année: 2021 | Type: Notes d'applications

This application note demonstrates the advantage of a lower hydrophobicity stationary phase that bears a charged surface potential, namely the CSH Phenyl-Hexyl stationary phase

Enhanced Recovery of Released Glycans Using QuanRecovery Sample Vials with MaxPeak High Performance ...
Référence Documentation: APNT135087970 | Format: PDF | Taille du fichier: 125.68 kB | Année: 2021 | Type: Notes d'applications

This work demonstrates how QuanRecovery Sample Vials with MaxPeak High Performance Surfaces (HPS) Technology can be used to increase recovery and stability of challenging analytes in the analysis of released glycans using HILIC-FLR/MS.

The BioAccord System With ACQUITY Premier for Improved Peptide CQA Monitoring
Référence Documentation: APNT135087979 | Format: PDF | Taille du fichier: 1033.42 kB | Année: 2021 | Type: Notes d'applications

The application note demonstrates the performance gains of the BioAccord configured with the inert ACQUITY Premier resulting in increased peptide recovery and robust MS response.

Improving Released N-glycan Analysis in Biotherapeutic Development Using the ACQUITY Premier Solutio...
Référence Documentation: APNT135084884 | Format: PDF | Taille du fichier: 748.69 kB | Année: 2021 | Type: Notes d'applications

This study demonstrates the new ACQUITY Premier System and Column technology improves the LC-FLR-MS data quality for released N-Glycan analysis.

Comprehending COVID-19: Distinct Identification of the SARS-CoV-2 Delta Variant Using the SARS-CoV-2...
Référence Documentation: APNT135087766 | Format: PDF | Taille du fichier: 395.06 kB | Année: 2021 | Type: Notes d'applications

This application brief demonstrates the Delta variant mutations can still be captured using SARS-CoV-2 LC-MS Kit (RUO) SISCAPA Ab and be selectively identified and differentiated from the wildtype peptide found in the other variants of concern using chrom...

Method Development of Ten Antibiotic Compounds Using a Systematic Screening Protocol on an ACQUITY A...
Référence Documentation: APNT135087733 | Format: PDF | Taille du fichier: 967.56 kB | Année: 2021 | Type: Notes d'applications

This application note demonstrates the benefits of a method development protocol based on a tiered screening approach, and its use towards developing a method to separate ten antibiotic compounds.

UPLC/MS Analysis of Mono-, Di- and Oligosaccharides Using ACQUITY UPLC BEH Amide Columns
Référence Documentation: APNT10130636 | Format: PDF | Taille du fichier: 249.38 kB | Année: 2021 | Type: Notes d'applications

This application brief highlights the UPLC-MS analysis of mono-, di-,and oligosaccharides using ACQUITY UPLC BEH Amide Columns.

Batch-to-Batch Robustness of MaxPeak Premier Columns for the Analysis Dexamethasone Phosphate and Re...
Référence Documentation: APNT135087660 | Format: PDF | Taille du fichier: 718.73 kB | Année: 2021 | Type: Notes d'applications

This application note demonstrates the robustness of MaxPeak Premier XSelect HSS T3 and XBridge BEH C18 Columns when used for the analysis of dexamethasone phosphate and related compounds.

Rapid Automated Antibody Purification Using Protein A-Coupled Magnetic Beads With Andrew+
Référence Documentation: APNT135087577 | Format: PDF | Taille du fichier: 1123.78 kB | Année: 2021 | Type: Notes d'applications

The application note details about the rapid antibody purification protocol, which is reproducible, robust, and can extract antibodies in a high yield from cell culture media.

Recovery of Metal-Sensitive Analytes on the Arc Premier Solution: System-to-System Reproducibility a...
Référence Documentation: APNT135087510 | Format: PDF | Taille du fichier: 979.8 kB | Année: 2021 | Type: Notes d'applications

In this study, the Arc Premier Solution will be tested with phosphorylated compounds that can interact with metallic surfaces to evaluate system-to-system performance.

Automated Sample Preparation Using Andrew+ Pipetting Robot for UPLC-MSE Identification and UPLC-MS/M...
Référence Documentation: APNT135087515 | Format: PDF | Taille du fichier: 850.87 kB | Année: 2021 | Type: Notes d'applications

This application note on the MaxPeak High Performance Surfaces (HPS) Technology that provides a highly effective surface barrier that mitigates undesired interactions with metal surfaces and improves the analysis of phosphopeptides found in casein.

QuEChERS Extraction of Per- and Polyfluoroalkyl Substances (PFAS) from Edible Produce with Sensitive...
Référence Documentation: APNT135087521 | Format: PDF | Taille du fichier: 1696.47 kB | Année: 2021 | Type: Notes d'applications

With a few minor adjustments to the extraction procedure, the QuEChERS based FDA Method C-010.01 was successfully used to analyze PFAS in a variety of different edible produce samples.

Modernized Impurity Analysis of the Kinase Inhibitor Imatinib by High-Resolution LC With MS-Compatib...
Référence Documentation: APNT135087532 | Format: PDF | Taille du fichier: 520.99 kB | Année: 2021 | Type: Notes d'applications

In this application note, the charged surface hybrid phenyl column and MS-compatible mobile phases to achieve significantly higher separation efficiency and selectivity for Imatinib and nine of its related impurities

Automated Sample Preparation Using Andrew+ Pipetting Robot for UPLC-MSE Identification and UPLC-MS/M...
Référence Documentation: APNT135087346 | Format: PDF | Taille du fichier: 850.93 kB | Année: 2021 | Type: Notes d'applications

This application note on the MaxPeak High Performance Surfaces (HPS) Technology that provides a highly effective surface barrier that mitigates undesired interactions with metal surfaces and improves the analysis of phosphopeptides found in casein.