Literature


Description
Method Transfer of a Fast Gradient from a Binary HPLC to an Arc HPLC System
Library Number: APNT135081867 | Format: PDF | File Size: 641.05 kB | Year: 2020 | Content Type: Application Notes

This application brief demonstrates the method transfer for a fast gradient method from an HPLC legacy system to the Arc HPLC System.

Improved Separation of RNA Nucleotides, Nucleosides, and Nucleobases on Atlantis Premier BEH Z-HILIC...
Library Number: APNT135086464 | Format: PDF | File Size: 933.35 kB | Year: 2021 | Content Type: Application Notes

This application note details about, the separation of thirteen RNA components is performed using four different stationary phases.

Increasing LC-MS accessibility for streamlined biotherapeutic analysis
Library Number: APNT135086419 | Format: PDF | File Size: 7035.24 kB | Year: 2021 | Content Type: Application Notes

We’ve curated multiple LC-MS application notes across many biopharmarelated applications to allow readers to explore the capabilities of the BioAccord LC-MS System to impact their own organizations.

Successful Global Cross Lab Method Transfer of a USP Organic Impurities Method to an Arc HPLC Using ...
Library Number: APNT135086166 | Format: PDF | File Size: 1240.61 kB | Year: 2021 | Content Type: Application Notes

In this application note, a global interlaboratory method transfer of a USP organic impurities method was conducted across eight sites around the world. The transfer was performed on Arc HPLC Systems.

Strategies for Targeted and Non-Targeted Screening and Differentiation of Cannabis Cultivars Using U...
Library Number: APNT135086349 | Format: PDF | File Size: 6092.54 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates a workflow for chemical profiling of cannabis cultivars.

A Method for the Extraction and Analysis of PFAS from Human Serum Utilizing Weak Anion Exchange (WAX...
Library Number: APNT135079462 | Format: PDF | File Size: 1352.6 kB | Year: 2021 | Content Type: Application Notes

This document outlines a complete SPE method for extraction of PFAS from human serum using Oasis WAX 96-well µElution plates with analysis on Xevo TQ-S micro.

Increased Sensitivity for LC-MS Analysis of Phosphopeptides on an ACQUITY QDa Detector Using XSelect...
Library Number: APNT135086104 | Format: PDF | File Size: 446.18 kB | Year: 2021 | Content Type: Application Notes

The work shown here demonstrates the improved MS sensitivity of phosphopeptides using a single quadrupole MS detector that can be achieved by using MaxPeak Premier Columns.

Determination of Aflatoxins in a Wide Range of Food and Agricultural Commodities Using Immunoaffinit...
Library Number: APNT135086046 | Format: PDF | File Size: 1083.27 kB | Year: 2021 | Content Type: Application Notes

The objective of this study was to evaluate the performance of the VICAM’s AflaTest WB SR+ column, using two separate HPLC/UPLC platforms.

evaluating_the_waters_acquity_premier_system_as_a_
Library Number: APNT135086060 | Format: PDF | File Size: 383.1 kB | Year: 2021 | Content Type: Application Notes

The goal of this study is to evaluate the ACQUITY Premier System as a flexible LC platform that can be broadly deployed across labs to support the analytical needs in the characterization and manufacturing of biotherapeutics.

Andrew+ Automated Mixed-Mode SPE Sorbent Selection Method Development for LC-MS Analysis
Library Number: APNT135085720 | Format: PDF | File Size: 389.13 kB | Year: 2021 | Content Type: Application Notes

This application brief demonstrates a rapid, accurate, reproducible, and robust mixed-mode SPE sorbent selection method development using human blood plasma spiked with four analytes(imipramine, 1-decanesulfonic acid, ketoprofen, and valethamate) for ion-...

Strategies for Targeted and Non-Targeted Screening and Differentiation of Cannabis Cultivars Using U...
Library Number: APNT135085598 | Format: PDF | File Size: 6092.54 kB | Year: 2021 | Content Type: Application Notes

In this study, a workflow for chemical profiling of cannabis cultivars will be demonstrated.

Rapid Identification of Adulteration in Edible Oils Using Direct Analysis Mass Detection Platform (R...
Library Number: APNT135084770 | Format: PDF | File Size: 378.43 kB | Year: 2021 | Content Type: Application Notes

RADIAN ASAP is a compact, robust, and easy-to-use system that enables rapid screening of samples.

Lipid Analysis Using the ACQUITY RDa Detector with SmartMS Technology and UNIFI Application
Library Number: APNT135084450 | Format: PDF | File Size: 720.29 kB | Year: 2021 | Content Type: Application Notes

Demonstrating the use of the ACQUITY RDa Detector for the robust reproducible analysis of target lipids in biological fluids.

Enhanced Performance for Basic Analytes at Low pH Using a CORTECS C18+ Column on an Agilent 1290 LC ...
Library Number: APNT135085324 | Format: PDF | File Size: 457.31 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates the separation of the Reversed-Phase QC Reference Material (RP-QCRM) on two different columns packed with superficially porous particles (SPP) and C18 ligands.

RADIAN ASAP for Simple Mass Spectral Screening of Polymer Formulations
Library Number: APNT135085268 | Format: PDF | File Size: 402.63 kB | Year: 2021 | Content Type: Application Notes

In this work, we illustrate the benefits of using fast, direct analysis with mass detection to discover and monitor polymer formulation additives as a complementary technique to traditional materials property measurement techniques such as thermal analysi...

Ion-Pairing Selection and Mixer Considerations in the Development of LC-MS Workflows
Library Number: APNT135085271 | Format: PDF | File Size: 655.2 kB | Year: 2021 | Content Type: Application Notes

This study demonstrates large volume mixers provide an effective means to reduce baseline noise in UV chromatograms while maintaining MS sensitivity for RPLC-based methods that incorporate FA as an ion-pairing reagent.

mAb Subunit Analysis Using the SYNAPT XS High Resolution Mass Spectrometer
Library Number: APNT135085063 | Format: PDF | File Size: 514.3 kB | Year: 2021 | Content Type: Application Notes

In this study, we compared the experiment results with data acquired under four different resolution modes: sensitivity, resolutio, high resolution, and enhanced resolution for analyzing the ~25 kD monoclonal antibody (mAb) IdeS digested subunits.

Utilization of the Arc Premier System and XSelect Premier Columns for Sensitive LC-MS Quantitation o...
Library Number: APNT135084971 | Format: PDF | File Size: 534.67 kB | Year: 2021 | Content Type: Application Notes

This application brief highlights the increased chromatographic performance for the metal sensitive steroid phosphate analytes, dexamethasone sodium phosphate, betamethasone sodium phosphate, and hydrocortisone phosphate triethylamine using the Arc Premie...

Analytical Quality by Design Based Method Development for the Analysis of Dexamethasone Phosphate an...
Library Number: APNT135084961 | Format: PDF | File Size: 808.17 kB | Year: 2021 | Content Type: Application Notes

In this application note, a UHPLC method for the analysis of metal-sensitive pharmaceuticals/related compounds using MaxPeak HPS systems and columns was developed.

Method Transfer of Size-Exclusion and Ion-Exchange Methods for Monoclonal Antibody Analysis from HPL...
Library Number: APNT135084969 | Format: PDF | File Size: 834.79 kB | Year: 2021 | Content Type: Application Notes

In this work, SEC and IEX methods are transferred from an Alliance HPLC System, an industry standard stainless-steel HPLC system, to an Arc Premier System, a modern UHPLC platform.

Challenge Accepted: Arc Premier System Increases Sensitivity and Reproducibility for Hard-to-See Com...
Library Number: APNT135084965 | Format: PDF | File Size: 1296.56 kB | Year: 2021 | Content Type: Application Notes

In this application note, we employ three applications to investigate the performance benefits achieved by the Waters Arc Premier System when paired with a MaxPeak Premier Column. The first application uses adenosine nucleotides as a probe to study the ef...

Seamless Method Transfer and Migration Between Instruments: Replicating an Aspirin and Related Subst...
Library Number: APNT135084891 | Format: PDF | File Size: 897.36 kB | Year: 2021 | Content Type: Application Notes

In this work, seamless migration of a related substances of aspirin active pharmaceutical ingredient (API) method to an Arc HPLC System is presented by demonstrating equivalent method performance.

Application of RADIAN ASAP-LiveID Platform in Flavor Type Discrimination of Chinese Baijiu and Authe...
Library Number: APNT135084767 | Format: PDF | File Size: 1088.26 kB | Year: 2021 | Content Type: Application Notes

In this application note, Waters RADIAN ASAP System was employed to discriminate the flavor type of different Chinese Baijiu, while the authenticity of Maotai was identified.

MaxPeak High Performance Surfaces Technology Improves HILIC Profiling of Released N-Glycans
Library Number: APNT135084776 | Format: PDF | File Size: 958.74 kB | Year: 2021 | Content Type: Application Notes

This application note illustrates improved glycan chromatographic recoveries and a new level of out-of-box performance, which is most pronounced for acidic glycans.

Screening Workflow for Extractables Testing of Medical Devices Using the UNIFI Scientific Informatio...
Library Number: APNT135084779 | Format: PDF | File Size: 1206.51 kB | Year: 2021 | Content Type: Application Notes

This application brief illustrates about the UNIFI Scientific Information System which provides analysts with a well-established workflow for extractable screening analysis of medical devices, supporting standards such as ISO 10993-18.