Literature


Description
The Analysis of Veterinary Drug Residues in Animal Muscle Tissue Using Multi-Residue Screening Based...
Library Number: APNT135080604 | Format: PDF | File Size: 1412.68 kB | Year: 2021 | Content Type: Application Notes

This application note describes the validation of a multiresidue method for the determination of residues of veterinary drugs from over 13 different classes in muscle tissue from various species, using the ACQUITY UPLC I-Class PLUS coupled to the Xevo TQ-...

Biotherapeutic Peptide Mass Confirmation and Impurity Profiling on a SmartMS Enabled BioAccord LC-MS...
Library Number: APNT135080322 | Format: PDF | File Size: 519.54 kB | Year: 2020 | Content Type: Application Notes

This application note demonstrates how BioAccord LC-MS System can be used for peptide mass confirmation and impurity profiling within research, development, and more highly regulated laboratories in manufacturing and QC.

Demonstrating the Waters ACQUITY RDa Detector as an Ease of Use Solution for Routine Accurate Mass M...
Library Number: APNT135080261 | Format: PDF | File Size: 1444.12 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates the forced degradation of simvastatin under acidic, basic and oxidative conditions.

Demonstration of LC-MS Nitrosamine Impurity Quantification Performance using Automated Sample Prepar...
Library Number: APNT135080267 | Format: PDF | File Size: 398.66 kB | Year: 2021 | Content Type: Application Notes

This application brief demonstrates automated calibration curve generation using the Andrew+ Pipetting Robot, with cloud-native OneLab Software, for accurate and reproducible LC-MS quantification of nitrosamine impurities, using an ACQUITY UPLC I-Class PL...

Determination of Oxyanions in Drinking Water by Direct Injection Using Liquid Chromatography-Tandem ...
Library Number: APNT135080258 | Format: PDF | File Size: 868.08 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates a direct injection method for the determination of chlorate, perchlorate, bromate and chlorite in drinking water that exceeds the requirements for the new EU Drinking Water Directive 2020.

The Analysis of Sudan and other Azo Dyes in Spices Using Liquid Chromatography-Tandem Quadrupole Mas...
Library Number: APNT135080263 | Format: PDF | File Size: 1017.68 kB | Year: 2021 | Content Type: Application Notes

In this application note we demonstrate the application of a simple approach for the determination of illegal dyes in paprika using UPLC-MS/MS after extraction of 11 dyes with a strong organic solvent, using stable isotope analogues as internal standards,...

UPLC-FLR Measurement of Flavanol and Procyanidin Bioactives In Cocoa-Based Commercial Products
Library Number: APNT135079406 | Format: PDF | File Size: 895.64 kB | Year: 2021 | Content Type: Application Notes

In this application note, we describe the implementation of AOAC2020.05 and the impact of system equilibration and sample treatment on the reliability of generated results.

Improving Drug Metabolite Identification in Biofluids with the ACQUITY PREMIER and Hybrid Organic Su...
Library Number: APNT135080192 | Format: PDF | File Size: 544.04 kB | Year: 2020 | Content Type: Application Notes

In this application note we demonstrate the benefit of using the ACQUITY PREMIER UPLC Chromatography System for the analysis of metabolites of gefitinib in mouse urine.

Improvements in Sensitivity for Quantification of Steroid Phosphate Drugs Using ACQUITY PREMIER and ...
Library Number: APNT135080188 | Format: PDF | File Size: 459.45 kB | Year: 2020 | Content Type: Application Notes

In this application note, we show the impact of using this novel surface for quantifying hydrocortisone phosphate and dexamethasone phosphate in extracts of human plasma.

Bypassing LC System Passivation Requirements Using ACQUITY PREMIER with MaxPeak HPS Technology for t...
Library Number: APNT135080176 | Format: PDF | File Size: 304.32 kB | Year: 2020 | Content Type: Application Notes

In this application brief, a peptide mixture containing a phosphorylated peptide is used to highlight performance differences observed between conventional LC technology and ACQUITY PREMIER with MaxPeak High Performance Surfaces (HPS) technology.

Enhancing the LC-MS/MS Analysis of B-group Vitamins with MaxPeak High Performance Surface Technology
Library Number: APNT135080184 | Format: PDF | File Size: 483.88 kB | Year: 2021 | Content Type: Application Notes

This application brief highlights the key improvements in chromatography using the ACQUITY PREMIER System and the ACQUITY PREMIER BEH C18 Column for the LC-MS/MS analysis of B-group vitamins.

Improved Analytical Sensitivity and Chromatographic Peak Shape for the Quantification of TCA Cycle A...
Library Number: APNT135080178 | Format: PDF | File Size: 1421.42 kB | Year: 2020 | Content Type: Application Notes

In this application note, we have demonstrated that the analysis of the TCA cycle and related metabolites in human plasma can be achieved with great analytical sensitivity when incorporating MaxPeak HPS Technology into the liquid chromatograph as well as ...

ACQUITY PREMIER LC Technology Significantly Improves Sensitivity, Peak Shape, and Recovery for Phosp...
Library Number: APNT135080182 | Format: PDF | File Size: 777.94 kB | Year: 2021 | Content Type: Application Notes

In this application note we show that the ACQUITY PREMIER CSH C18 Column with ACQUITY PREMIER System can significantly improve sensitivity, peak shape, and recovery of phosphorylated and carboxylate lipids compared to ACQUITY standard column and stainless...

PREMIER Standards to Investigate the Inertness of Chromatographic Surfaces
Library Number: APNT135080186 | Format: PDF | File Size: 433.54 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates the ability to assess the inertness of the recently introduced ACQUITY PREMIER System, which has been designed to eliminate metal-analyte secondary interaction.

Advantages of using ACQUITY PREMIER System and Columns with MaxPeak HPS Technology for Bioanalysis o...
Library Number: APNT135080190 | Format: PDF | File Size: 235.85 kB | Year: 2021 | Content Type: Application Notes

In this application brief, we investigate the effect of these novel hybrid barrier surface technologies on metal insensitive compounds. Gefitinib (Iressa) was chosen as a candidate molecule for this study.

Utilization of the ACQUITY PREMIER System and Column for Improved Oligonucleotide Bioanalytical Chro...
Library Number: APNT135080196 | Format: PDF | File Size: 697.79 kB | Year: 2021 | Content Type: Application Notes

LC-MS/MS bioanalytical quantification of oligonucleotide therapeutics requires sensitive and robust analytical methods for their accurate quantification. This work highlights the increased chromatographic performance for oligodeoxythymidines (ODTs) and th...

Maximizing Phosphopeptide Recovery in LC-MS Studies with MaxPeak High Performance Surfaces Technolog...
Library Number: APNT135080180 | Format: PDF | File Size: 681.64 kB | Year: 2020 | Content Type: Application Notes

The data described in this application note compares the performance between a conventional system and HPS treated system to investigate the phosphopeptide response.

Demonstrating Improved Sensitivity and Dynamic Range with MaxPeak High Performance Surface (HPS) Tec...
Library Number: APNT135080194 | Format: PDF | File Size: 458.33 kB | Year: 2020 | Content Type: Application Notes

This case study shows when and how chromatographic surfaces can be of significant influence for analyte detection.

Practical Instrument Considerations for Ion-Exchange Chromatography-Mass Spectrometry (IEX-MS)
Library Number: APNT135080129 | Format: PDF | File Size: 321.21 kB | Year: 2021 | Content Type: Application Notes

Ion-Exchange Chromatography (IEX) for proteins has historically been incompatible with mass spectrometry (MS) due to the use of high concentrations of salt.

Multiresidue Method for the Quantification of Pesticides in Fruits, Vegetables, Cereals and Black Te...
Library Number: APNT135072936 | Format: PDF | File Size: 1584.67 kB | Year: 2020 | Content Type: Application Notes

In this application note we demonstrate a multi-residue UPLC-MS/MS method developed for the determination of 552 pesticides and relevant metabolites for pesticide residue analysis.

Comprehending COVID-19: Structural Characterization of the Glycan Assemblies of O-linked Glycopeptid...
Library Number: APNT135078200 | Format: PDF | File Size: 777.69 kB | Year: 2021 | Content Type: Application Notes

This application exploits Waters SELECT SERIES Cyclic IMS instrument for the characterization of the glycan structures and linkages of O-linked glycopeptides.

A Method for the Extraction and Analysis of PFAS from Human Serum Utilizing Weak Anion Exchange (WAX...
Library Number: APNT135079462 | Format: PDF | File Size: 1106.94 kB | Year: 2021 | Content Type: Application Notes

This document outlines a complete SPE method for extraction of PFAS from human serum using Oasis WAX 96-well µElution plates with analysis on Xevo TQ-S micro.

A Streamlined Compliant Ready Workflow for Peptide-Based Multi-Attribute Method (MAM)
Library Number: APNT135079459 | Format: PDF | File Size: 1185.5 kB | Year: 2020 | Content Type: Application Notes

This application note demonstrates an end-to-end analytical workflow developed for peptide-based multi-attribute method (MAM).

Rapid AAV Concentration Determination Using Size-Exclusion Chromatography with Fluorescence and UV D...
Library Number: APNT | Format: PDF | File Size: 930.22 kB | Year: 2021 | Content Type: Application Notes

In this application note we present a rapid SEC method (two minutes) with FLR detection for the determination of AAV capsid concentration (Cp/mL).

The ACQUITY RDa for Routine Food Profiling – Detecting the Unexpected in Honey
Library Number: APNT135079338 | Format: PDF | File Size: 690.37 kB | Year: 2021 | Content Type: Application Notes

This application note investigates whether untargeted metabolomics could differentiate honey samples from polyfloral and single botanical origin and detect illicit fortification of a honey supplement, using a novel high-performance bench-top orthogonal ac...