Modernized Impurity Analysis of the Kinase Inhibitor Imatinib by High-Resolution LC With MS-Compatible Mobile Phases

資料庫編號:
APNT135087532
零件編號:
720007340EN
作者:
Peng Chen, Bonnie A. Alden, Matthew A. Lauber
資源:
Waters
內容類型:
應用手冊
內容次分類:
應用手冊
相關產品:
 
 
 
 
 

The use of UPLC with an ACQUITY Premier CSH Phenyl-Hexyl Column has facilitated the modernization of an EP method to analyze imatinib and its impurities. Considerations on L/dp and MS compatibility were applied to develop a separation that produces excellent peak shape and resolution for imatinib and nine of its impurities. Sensitive impurity analysis was made possible through both optical detection and accurate mass time-of-flight MS analysis.


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