Migration of an HILIC Method for Released Glycan Analysis from the ACQUITY UPLC H-Class PLUS Bio System to the Arc Premier System

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Robert E. Birdsall, Jacob Kellett, Ying Qing Yu
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Method migration is a key process in the development of biopharmaceuticals and is part of the lifecycle management for analytical procedures. Successful method migration requires that comparable performance is maintained throughout the lifecycle of the method. The Arc Premier System produced consistent peak % area and relative retention time results with an HILIC method migrated from an ACQUITY UPLC H-Class PLUS Bio System. This demonstrates that the Arc Premier System is well suited to support the development and manufacturing activity of biopharmaceuticals.

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