Mass Analyzers for LC-MS by Filip Lemière
The major technical challenge in liquid chromatography–mass spectrometry (LCMS) is interfacing the chromatographic and spectrometric components. This observation implies that any mass spectrometer potentially can be coupled to an LC or other separation system. Understanding the different working principles and technical properties of different MS instruments gives an insight into the technical possibilities and limitations that must be acknowledged when coupling MS with LC. The characteristics of different MS instruments also determine their applications in the various LC-MS research fields, and the requirements imposed by the analytical question determine the type of MS to couple to the LC system. Ultimately, the only limit to the coupling of LC to MS is the imagination of the analyst setting up the hyphenated experiment.