Fast and Easy SPE Method Development Strategies for the Determination of Drugs in Biological Matrices

Library Number:
980279
Author(s):
Waters [Y-F. Cheng et al.]
Source:
Waters Seminar
Content Type:
Seminars
Compounds:
Antidepressants; Sulfamerazine; Ibuprofen; Naproxen; Salicylic acid; Minocycline; Tetracycline; Demeclocycline; Verapamil; Methoxyverapamil; Norverapamil; Betamethasone; Acetaminophen; Ranitidine; Procainamide; Theophylline; Theobromine; Caffeine; Oxycodone; Naltrexone; Salbutamol; Paraxanthine; Sulfadiazine; Propranolol; Dipropyl phthalate; Betamethasone valerate; Enalapril; Enalaprilat; Nordoxepin; Nortriptyline; Doxepin; Imipramine; Amitriptyline; Trimipramine; Benzoic acid; Catechol; Toluamide; m-Toluidine; Trazodone; 1-(3-Chlorophenyl)piperazine dihydrochloride; Maprotiline; Succinyl-sulfathiazole; Sulfamethazine; Sulfamethoxazole
Matrix:
human plasma, porcine serum
Column:
SymmetryShield RP8 3.5 µm,5 µm Sentry Symmetry C18
Dimensions:
4.6 x 75 mm; 3.9 x 150 mm
Sample preparation is required to maximize the quality of the analytical results and to minimize the downtime of expensive, high-overhead analytical tools such as LC/MS/MS systems. Traditionally, sample preparation was the bottleneck in laboratory productivity since the method was difficult to automate. Presently, solid-phase extraction (SPE) has proven to be easily automated for high sample throughput analysis.

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