Identification and Quantitation of Ginkgolides and Bilobalides in Chinese Herbal Medicines

Library Number:
Khan, T[1];Kearney, G[1];Farook, A[1];Long-Sheng, S[2]
ASMS 2002; Orlando; 3rd-6th June
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--Ginkgo biloba is a tree that has, since ancient times, been used as a component of traditional Chinese herbal medicines --Ginkgoldies, the main components of preparations of Ginkgo leaf and root, are now being developed as therapeutic agents. --In order to quantify known components of Ginkgo biloba leaf, fast gradient HPLC separations were coupled to MRM anlyses on a Quattro Micro triple quadrupole mass spectrometer (Micromass UK Ltd., Manchester, UK) --Quantification methods show good sensitivity, dynamic range and precision. --In order to ascertain the identity of other components in the leaf preparation a slow HPLC gradient was coupled to high-resolution, accurate-mass analysis using a Q-Tof Ultima hybrid quadrupole/oaToF mass spectrometer (Micromass UK Ltd., Manchester, UK). --A range of compounds and structural isomers were identified in the mixture

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