Compound Purification Workflow Management and Optimization

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Paul M. Lefebvre, Andrew Brailsford, David Brindle, Clare North, Ronan Cleary, Warren B. Potts III, Brian W. Smith
Pittcon 2003, Orlando, FL, March 9-14, 2003
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Traditionally, drug discovery laboratories have screened large libraries with mininal to no purity requirements. Today, laboratories screen libraries that are smaller and more focused with specific purity limits, typically 85% or greater. This places a greater burden on the overall purification process. Efficiently managing this burden requires purification strategies that dovetail into the overall synthesis-to-screen process. This poster illustrates how a compound library is taken through a purification process, using the Waters AutoPurify Software.

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