Innovative Sample Preparation Technology Enabling High Sensitive MALDI MS Analysis
This work presents a simple and robust sample preparation technology for MALDI-MS analysis by using a novel MALDI target plate, the Waters® Micromass® MassPREP PROtarget Plate. The PROtarget Plate is a uniquely-designed MALDI target plate that enables sample preparations directly on the target. A large volume (up to 10 µL) of diluted sample is placed on the target plate and dries down with focusing to a confined region coated by a membrane having peptide binding property. The region is then subsequently washed to remove contaminants that are contained in sample and may interfere with MALDI analysis, whereas analytes are selectively adsorbed onto the membrane and enriched.