Evaluation of UPLC/MS/MS for the Validated Bioanalytical Quantification of Amitriptyline in Human Plasma

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Tabisam Khan, Lisa Calton, Steve Preece (Waters, Manchester, UK), Cozette Cuppett (Waters, Milford, MA USA)
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Other Symposium
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In this work we present a method of analysis for Amitriptyline, a common anti-depressant, in human plasma that has been validated on a HPLC/MS/MS system to the strict guidelines required by the FDA. This analysis was then compared to a method developed for a new UPLC/MS/MS system that has made the analysis more sensitive and faster. Incorporating ultra performance liquid chromatography technology with the latest technology in tandem quadrupole mass spectrometry has resulted in a faster and more sensitive approach to quantitative bioanalysis. This poster was shown at: American Association of Pharmaceutical Scientists (AAPS), Baltimore, Maryland, November 7-11, 2004.

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