The Application of Sub 2 um Porous Chromatographic Particles with Operating Pressures up to 15,000 PSI for Analysis of Pharmaceutical Compounds in Biological Fluids

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Warren Potts, Robert Plumb, Jose Castro-Perez, Jennifer Granger, Kate Yu
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A new novel organo-silica hybrid 1.7 µm porous particle stationary phase has been developed for liquid chromatography. This material has been combined with a new liquid chromatography system with a 100 µL delay volume capable of operating at pressures up to 15,000 psi with enhanced diagnostics. The combination of these technologies has allowed a new region of chromatographic space to be exploited. With this new technology chromatographic resolution is improved by a factor of 1.7–3, increased sensitivity by a factor of 3–8 and throughput increased by a factor of 5–10. This technology, Ultra Performance Liquid Chromatography (UPLC™), has been combined with mass spectrometry for the analysis of biological fluids. This poster was shown at: Montreux LC/MS Symposium on LC/MS, SFC/MS, CE/MS and MS/MS, Montreux, Switzerland, November 10-12, 2004

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