Over the last few years there has been an increasing interest in the use of oral fluid to document drug use. The advantage of this specimen over the more traditional matrices e.g. urine and blood, is that collection is almost non-invasive, relatively easy to perform, and may be achieved under close supervision to prevent adulteration or substitution of the sample. LC/MS/MS is a technique that lends itself well to the high-throughput determination of multiple analytes in oral fluid samples due to its high specificity, sensitivity and short analysis times.
This poster was shown at: Montreux LC/MS Symposium on LC/MS, SFC/MS, CE/MS and MS/MS, Montreux, Switzerland, November 10-12, 2004.