Developing SPE Methods: Outlining a Systematic Approach
By careful examination of the physical-chemical nature of the
analytes combined with the characteristics of the sorbents, a
systematic approach to SPE method development was developed. Using this
approach as well as understanding the pitfalls from sample
pre-treatment to elution will result in robust SPE methods.
Additionally, by paying close attention to the sample diluent and
mobile phase conditions, sensitivity and peak shapes can be