Developing SPE Methods: Outlining a Systematic Approach

Library Number:
WA40532
Part Number:
WA40532
Author(s):
Ziling Lu, Diane M. Diehl, Claude Mallet, and Jeffrey R. Mazzeo Waters Corporation
Source:
2004 AAPS Annual Meeting and Exposition, November 7-11, Baltimore MD
Content Type:
Posters
Content Subtype:
AAPS
Related Products:
By careful examination of the physical-chemical nature of the analytes combined with the characteristics of the sorbents, a systematic approach to SPE method development was developed. Using this approach as well as understanding the pitfalls from sample pre-treatment to elution will result in robust SPE methods. Additionally, by paying close attention to the sample diluent and mobile phase conditions, sensitivity and peak shapes can be optimized.

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