Matrix Effects Eliminated by a Simple and Fast Sample Preparation Method - Mixed-Mode SPE
Our results indicate that protein precipitation causes
significant ion suppression and is the least effective sample
preparation technique. SPE methods result in cleaner extracts.
Mixed-mode (i.e. contains both reversed-phase and ion exchange
retention mechanisms) SPE method eliminates matrix interferences
effectively from biological samples. The remaining phospholipid matrix
effects are less than 0.5%.