A Novel Ultra-HTS Method by UPLC-MS for Metabolite Detection and Identification
From the data presented the advantages of using this novel
UPLC-TOF-MS approach for metabolism studies are obvious. As technology
progresses, we are obtaining better levels of detection not only via a
more sensitive assay, but through better quality data. Using UPLC-TOFMS
adds a new dimension to metabolism studies enabling us to obtain better
detection limits, better throughput and increased chromatographic
resolution, which in turn will improve the data quality from the mass
spectrometer. It is a major leap forward, not just for this application
but many others in both qualitative and quantitative bioanalysis. This
poster was presented at ISSX Drug Metabolism in Vancouver, Aug.
29-Sept. 1, 2004.