A Novel Ultra-HTS Method by UPLC-MS for Metabolite Detection and Identification

Library Number:
Part Number:
Waters Corporation: Jose Castro-Perez, Jennifer Granger, Andrew Baker, Robert Plumb. AstraZeneca R&D Charnwood: Iain Beattie, Karine Joncour, Andy Wright.
Content Type:
Content Subtype:
Other Symposium
Related Products:
From the data presented the advantages of using this novel UPLC-TOF-MS approach for metabolism studies are obvious. As technology progresses, we are obtaining better levels of detection not only via a more sensitive assay, but through better quality data. Using UPLC-TOFMS adds a new dimension to metabolism studies enabling us to obtain better detection limits, better throughput and increased chromatographic resolution, which in turn will improve the data quality from the mass spectrometer. It is a major leap forward, not just for this application but many others in both qualitative and quantitative bioanalysis. This poster was presented at ISSX Drug Metabolism in Vancouver, Aug. 29-Sept. 1, 2004.

Title Format File Size
720000974en PDF 223.21kB