A Novel Approach to Metabolite Detection and Identification by the Use of UPLC/Hybrid Quadrupole Travelling Wave IMS-oa-Tof
This poster was presented at ASMS 2006. Typically one of the main problems with metabolite ID samples are the biological matrices analyzed. These samples may contain a very large number of endogenous compounds which may interfere with the detection of the drug-related component or may obscure its detection. This is true, for example, in the case of bile, where there is a high content of bile salts and sometimes these co-elute with putative metabolites. In this work we have utilized a Travelling Wave Ion Mobility Spectrometry (IMS) TOF to detect and separate endogenous metabolites from xenobiotics.