A Novel Approach to Metabolite Detection and Identification by the Use of UPLC/Hybrid Quadrupole Travelling Wave IMS-oa-Tof

Library Number:
720001715EN
Part Number:
720001715EN
Author(s):
Jose Castro-Perez, John Shockcor, Kevin Giles, Steve Pringle, Robert Bateman, Jason Wildgoose, Alan Millar (Waters);Iain Beattie (AstraZeneca)
Source:
ASMS 2006 May 28-June 1 Seattle, Wa
Content Type:
Posters
Content Subtype:
ASMS
Related Products:
SYNAPT HDMS
This poster was presented at ASMS 2006. Typically one of the main problems with metabolite ID samples are the biological matrices analyzed. These samples may contain a very large number of endogenous compounds which may interfere with the detection of the drug-related component or may obscure its detection. This is true, for example, in the case of bile, where there is a high content of bile salts and sometimes these co-elute with putative metabolites. In this work we have utilized a Travelling Wave Ion Mobility Spectrometry (IMS) TOF to detect and separate endogenous metabolites from xenobiotics.

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