An Automated UPLC/MS/MS Approach to Enhance the Throughput of Physicochemical Property Profiling in Drug Discovery

Library Number:
720002322EN
Part Number:
720002322EN
Author(s):
Darcy Shave, Peter G. Alden, Paul Lefevbre, Rob Plumb, Warren Potts
Content Type:
Posters
Content Subtype:
Montreux
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Experiments including solubility, chemical and biological stability, water/octanol partioning, PAMPA, Caco-2, and protein binding are used to generate physicochemical profiles of compounds in drug discovery. The measurement of physicochemical properties from these studies is easily enabled using chromatographic separation and quantitation using LC/MS/MS/UV. While the sample analyses may be efficient, the processing of the data and the interpretation of the results often requires tedious and time-consuming manual manipulation and calculation. This paper describes an approach to solving these problems by the use of a novel software package that allows for the design of experiments, data acquisition, and the processing as well as report generation in a fully automated manner.

 


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