Fast and accurate analytical methods are essential to keep pace with sample libraries produced from combinational chemistry and high throughput biological screening. Many laboratories now use a combination of ionisation techniques for the characterisation of these samples including Atmospheric Pressure Chemical Ionisation (APCI), Electrospray Ionisation (ESI) and Photoionisation (PI).
In this poster we present findings for a new combined APCI-ESI source, the Waters ESCi Multi-Mode Ionization Source, for use in HPLC applications. The combined source allows alternate on-line APCI-ESI scans within a single analysis. The performance of the combined source has been compared to the existing APCI and ESI interfaces and found to be equivalent.