Novel Porous Resins with Dual Ion-Exchange/Reversed-Phase Retention Behavior

Library Number:
Jeng-Jong Peter Lee, JE O''Gara;DP Walsh;AR Pelissey;ESP Bouvier;PC Iraneta;Henry Cheng;DJ Phillips
HPLC''99 Granada Spain June 2nd 1999
Content Type:
Content Subtype:
SPE Format:
Oasis HLB Cartridge Oasis MCX Cartridge Oasis MAX Cartridge
Methadone & metabolite; Estazolam; Metoprolol; Oxprenolol; Codeine & metabolite; Toluamide; Methoxyverapamil; Verapamil; Amphetamine; Methamphetamine; Caffeine; nor-Verapamil; Barbital; Toluidine; Procainamide; Ranitidine; Acetaminophen
Plasma; human urine
Analytical Techniques:
In 1996, Waters designed and commercialized the Oasis® HLB sorbent, a water-wettable copolymer with hydrophilic-lipophilic balance (HLB) for SPE. Unique in its ability to retain both polar and non-polar compounds and their metabolites, with high reproducibility and recovery, Oasis® HLB sorbent has set the new standard for SPE. In order to meet the demand for extraction of basic or acidic drugs, Oasis® MCX, a new member of the Oasis® family has been developed. It has exhibited high selectivity and sensitivity for extracting basic drugs. Furthermore, Oasis® MAX for acidic drugs is also being developed. Oasis® MCX and MAX are brand new porous resins having a hydrophobic fragment, a hydrophilic polar moiety, and an ion-exchange functional group. In this paper, we would like to discuss their synthesis, selectivity, reproducibility and recovery. In addition, an example of using Oasis® MCX as a universal sorbent for isolating acidic, basic, and neutral drugs will be reported.

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