Novel Porous Resins with Dual Ion-Exchange/Reversed-Phase Retention Behavior
In 1996, Waters designed and commercialized the Oasis® HLB
sorbent, a water-wettable copolymer with hydrophilic-lipophilic balance
(HLB) for SPE. Unique in its ability to retain both polar and non-polar
compounds and their metabolites, with high reproducibility and
recovery, Oasis® HLB sorbent has set the new standard for SPE. In order
to meet the demand for extraction of basic or acidic drugs, Oasis® MCX,
a new member of the Oasis® family has been developed. It has exhibited
high selectivity and sensitivity for extracting basic drugs.
Furthermore, Oasis® MAX for acidic drugs is also being developed.
Oasis® MCX and MAX are brand new porous resins having a hydrophobic
fragment, a hydrophilic polar moiety, and an ion-exchange functional
group. In this paper, we would like to discuss their synthesis,
selectivity, reproducibility and recovery. In addition, an example of
using Oasis® MCX as a universal sorbent for isolating acidic, basic,
and neutral drugs will be reported.