An Investigation of Traveling Wave and Drift Tube IMS Separations of Protein Ion Charge States and their Fragments

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Jean Marie Casanova, Steven Pringle, Kevin Giles, Robert Bateman (Waters);Stormy L Koeniger, David E Clemmer (Department of Chemistry, Indiana University);Stephen Valentine (Predictive Physiology and Medicine)
IMSC 2006, Aug. 27-Sept. 1, Prague; Journées Midi-Pyrénnées Dec 12, 2006, Toulouse, France
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In this poster, we compare two new ion mobility spectrometry techniques; Travelling Wave Ion Mobility and Tandem Drift Tube IMS for the separation of fragment ions from intact proteins according to ion charge states and their cleavage type. Similar results were obtained both in terms of spectral decongestion and the ability to extract families of ions corresponding to specific fragment ion types and charge states. This poster was presented at the 17th International Mass Spectrometry Conference (IMSC), Aug. 27-Sept. 1, 2006 in Prague.

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